去乙酰化酶Sirtuins家族与放射性肝病的关系

Association between deacetylase Sirtuins and radiation-induced liver disease

放射性肝病(RILD)或称放射性肝炎,是一种由辐射引起的亚急性肝损伤。去乙酰化酶家族Sirtuins(SIRTs)作为衰老相关研究的焦点具有DNA修复和染色质调节等分子功能,是基因组和表观基因组稳定性的枢纽。辐射诱导的肝脏DNA损伤和反应是RILD主要的生理病理过程,这与SIRTs表征的功能相似。本文简述了SIRTs蛋白家族的结构和功能,回顾了放射治疗的物理生理学基本概念及进展,主要从放射生物学角度分析了SIRTs与RILD二者的内在关系,指出SIRTs作为RILD防治靶点的可能性。

Radiation-induced liver disease(RILD),also known as radiation hepatitis,is subacute liver injury induced by radiation.As the focus of senescence-related studies,the deacetylase family Sirtuins(SIRTs)have the molecular functions including DNA repair and chromatin regulation,which makes SIRTs a hub for regulating genome and epigenome stability.Radiation-induced hepatic DNA damage and reaction is the primary physiological and pathological process of RILD,which is similar to the function of SIRTs.This article briefly introduces the structure and function of the SIRTs protein family,elaborates on the basic concepts and progress of the physical physiology of radiation therapy,discusses the internal relationship between SIRTs and RILD from the perspective of radiobiology,and points out the possibility of SIRTs as a target for the prevention and treatment of RILD.