防治儿童口腔黏膜炎的临床研究

Clinical Study on Prevention and Treatment of Oral Mucositis in Children

儿童口腔黏膜炎是儿科肿瘤患者在化疗、放疗等治疗后常见的并发症,具有发病率高、防治棘手等特点。近年来学者们对防治儿童口腔黏膜炎方法的安全性和有效性开展了临床研究,如帕利夫明、重组人粒细胞巨噬细胞刺激因子、激光、光动力、冷冻疗法、过饱和磷酸钙含漱液、氯己定含漱液、Mucosamin喷雾剂、聚普瑞锌海藻酸钠悬浮液、蜂蜜、维生素E等。本文就防治儿童口腔黏膜炎的临床研究做一综述,以期为儿童口腔黏膜炎的防治和临床研究提供参考。

Oral mucositis is a common complication in pediatric oncology patients after chemotherapy and radiotherapy treatments,which is characterized by high incidence and tricky prevention and treatment.In recent years,scholars have conducted clinical studies on the safety and efficacy of some methods to prevent and treat oral mucositis in children,such as palifermin,laser,photodynamic therapy,cryotherapy,supersaturated calcium phosphate,chlorhexidine,mucosamin spray,polaprezinc zinc-L-carnosine,honey,and vitamin E.This paper presents a review of clinical studies on the prevention and treatment of oral mucositis in children,with the aim to provide reference for the prevention and treatment of oral mucositis in children.