分泌粒蛋白Ⅲ在糖尿病性视网膜病变新生血管形成中的作用及意义

Effect and significance of secretogranin Ⅲ in diabetic retinal neovascularization

分泌粒蛋白Ⅲ(SCG3)是一种广泛分布于人体组织和细胞中的具有内分泌功能的蛋白颗粒。其作为粒蛋白家族(granin家族)中的一员,通常被认为参与内分泌和神经分泌的调节活动,同时也作为一种高度特异性的血管生成因子,在糖尿病性视网膜病变(DR)和早产儿视网膜病变动物模型中发挥减轻视网膜血管渗漏和新血管形成的作用。除此之外,SCG3还与炎症因子、抗脑源性神经营养因子等在神经细胞中共表达。本文综述了目前对SCG3作为分泌颗粒蛋白以及其粒蛋白家族的认识,分析了SCG3在体内的分布,讨论了其在血管新生方面的作用,认为SCG3与新生血管的形成存在相关性,同时重点探讨了SCG3在DR中可能存在的作用及意义,特别是与微血管病变、炎症因子及视网膜神经变性相关的作用;通过比较SCG3与血管内皮生长因子(VEGF)在信号通路与相关受体结合等方面的差异,对抗SCG3药物治疗DR的效果和优势进行展望。

SecretograninⅢ(SCG3)is a kind of secretory granule widely distributed in tissues and cells with endocrine functions in the human body.As a member of the granin family,it is generally considered to be involved in endocrine and neuroendocrine regulatory activities,and also as a highly disease-selective angiogenic factor that reduces vascular leakage and neovascularization in animal models of diabetic retinopathy and retinopathy of prematurity.In addition,SCG3 also co-expresses with inflammatory factors,anti-brain-derived neurotrophic factors in nerve cells.This article reviewed the current understanding of SCG3 as a secretory granular protein and its granulocyte family,analyzed the distribution of SCG3 in vivo,discussed its role in angiogenesis,and considered the correlation between SCG3 and neovascularization.It focused on the possible role and significance of SCG3 in diabetic retinopathy,especially in relation to microangiopathy,inflammatory factors and retinal neurodegeneration.By comparing the differences between SCG3 and vascular endothelial growth factor(VEGF)in the binding of signaling pathways and related receptors,the effects and advantages of anti-SCG3 drugs in the treatment of DR were prospected.