血清Galectin-9、CXCL10对老年结肠癌伴冠心病患者化疗相关心脏毒性的预测效能

Predictive Efficacy of Serum Galectin-9 and CXCL10 for Chemotherapy-related Cardiotoxicity in Elderly Patients with Colon Cancer and Coronary Heart Disease

目的探讨血清半乳糖凝集素-9(Galectin-9)、CXC趋化因子配体10(CXCL10)对老年结肠癌伴冠心病患者化疗相关心脏毒性的预测效能。方法选取2020年1月—2023年1月收治104例伴有冠心病的老年结肠癌为研究对象,根据是否发生化疗相关心脏毒性事件分为无心脏毒性组76例与有心脏毒性组28例。比较2组血清Galectin-9、CXCL10水平,采用受试者工作特征曲线评估血清Galectin-9、CXCL10对老年结肠癌伴冠心病患者化疗相关心脏毒性的预测价值,采用多因素Logistic回归分析探讨老年结肠癌伴冠心病患者化疗相关心脏毒性的影响因素。结果有心脏毒性组血清Galectin-9、CXCL10水平高于无心脏毒性组(P<0.01)。血清Galectin-9、CXCL10预测老年结肠癌伴冠心病患者化疗相关心脏毒性的曲线下面积(AUC)分别为0.805、0.739,特异度分别为64.76%、56.87%,敏感度均为91.45%。二者联合预测的AUC为0.906,特异度为86.97%,敏感度为87.47%。左心室射血分数≤51.74%、血清Galectin-9≥10.81μg/L、血清CXCL10≥127.24 pg/mL是老年结肠癌伴冠心病患者化疗相关心脏毒性的独立危险因素(P<0.01)。结论血清Galectin-9、CXCL10水平升高与老年结肠癌伴冠心病患者化疗相关心脏毒性密切相关,可作为评估患者化疗相关心脏毒性的生物学指标,且二者联合预测的效能更高。

Objective To explore the predictive efficacy of serum Galectin-9 and CXC chemokine ligand 10(CXCL10)in chemotherapy-related cardiotoxicity in elderly colon cancer patients with coronary heart disease(CHD).Methods A total of 104 elderly patients with colon cancer and CHD admitted from January 2020 to January 2023 were selected as the research subjects.According to occurrence of chemotherapy-related cardiotoxic events,they were divided into the non-cardiotoxicity group(n=76)and the cardiotoxicity group(n=28).Serum Galectin-9 and CXCL10 levels were compared between the two groups,and the predictive value of serum Galectin-9 and CXCL10 in chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD was evaluated by receiver operating characteristic curve.Multivariate Logistic regression analysis was used to investigate the influencing factors of chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD.Results The levels of Galectin-9 and CXCL10 in the cardiotoxicity group were higher than those in the non-cardiotoxicity group(P<0.01).The area under the curve(AUC)of serum Galectin-9 and CXCL10 was 0.805 and 0.739 respectively,the specificity was 64.76% and 56.87% respectively,and the sensitivity of both was 91.45%.The AUC of combined detection in prediction was 0.906,the specificity was 86.97%,and the sensitivity was 87.47%.Left ventricular ejection fraction≤51.74%,serum Galectin-9≥10.81μg/L,and serum CXCL10≥127.24 pg/mL were independent risk factors for chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD(P<0.01).Conclusion Increased serum Galectin-9 and CXCL10 levels are closely related to chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD,and can be used as biological indicators to evaluate chemotherapy-related cardiotoxicity in patients,and the combined prediction of the two is more effective.