支气管哮喘患儿血清IL-8、IL-33水平与肺功能指标的相关性

Correlation between serum IL-8,IL-33 levels and lung function indicators in children with bronchial asthma

目的探讨支气管哮喘患儿血清白细胞介素-8(IL-8)和白细胞介素-33(IL-33)水平与肺功能指标的相关性。方法选取该院儿科哮喘门诊2023年1-6月收治的60例支气管哮喘患儿作为研究组,根据支气管哮喘严重程度将研究组患儿分为轻度组(22例)、中度组(27例)和重度组(11例),另选取同期于该院就诊的60例气管异物或气道畸形的非哮喘患儿为对照组。比较研究组与对照组,以及不同病情严重程度患儿间的血清IL-8、IL-33水平,采用Pearson相关分析支气管哮喘患儿血清中IL-8、IL-33水平与各项肺功能指标的相关性;采用受试者工作特征(ROC)曲线分析患儿血清IL-8、IL-33对重度支气管哮喘的诊断价值。结果研究组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、第1秒用力呼气容积占预计值百分比(FEV1%pre)、用力呼气50%时的瞬间流速(FEF50%)及最大呼气中期流速(FEF25%~75%)均低于对照组,差异有统计学意义(P<0.05);研究组血清IL-8和IL-33水平均高于对照组,差异有统计学意义(P<0.05);轻度组、中度组、重度组血清IL-8和IL-33水平依次升高,两两比较,差异有统计学意义(P<0.05);血清IL-8、IL-33水平与肺功能指标均呈负相关(P<0.05);血清IL-8和IL-33联合检测诊断重度支气管哮喘的曲线下面积(AUC)为0.861,大于血清IL-8(0.660)和IL-33(0.681)单独检测的AUC(Z=2.579、1.978,P=0.023、0.047)。结论支气管哮喘患儿血清IL-8和IL-33水平与各肺功能指标密切相关,二者联合检测对重度支气管哮喘具有较高的诊断价值。

Objective To investigate the relationship between serum interleukin-8(IL-8),interleukin-33(IL-33)levels and pulmonary function in children with bronchial asthma.Methods A total of 60 children with bronchial asthma admitted to the pediatric asthma clinic of the Second Affiliated Hospital of Hainan Medical College from January to June 2023 were selected as the study group.According to the severity of bronchial asthma,the study group was divided into mild group(22 cases),moderate group(27 cases)and severe group(11 cases).In addition,60 non-asthmatic children with tracheal foreign body or airway malformation treated in the same hospital during the same period were selected as the control group.The serum levels of IL-8 and IL-33 were compared between the study group and the control group,among the children with different severity of the disease.Pearson correlation analysis was used to analyze the correlation between the serum levels of IL-8,IL-33 and various lung function indexes in children with bronchial asthma.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum IL-8 and IL-33 in children with severe bronchial asthma.Results The FEV1,FVC,FEV1/FVC,FEV1% pre,FEF50% and FEF25%-75% in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The serum levels of IL-8 and IL-33 in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).The serum levels of IL-8 and IL-33 in the mild group,moderate group and severe group increased in turn,the differences were statistically significant(P<0.05).The serum levels of IL-8 and IL-33 correlated negatively with pulmonary function indexes(P<0.05).The area under the curve(AUC)of the combined detection of serum IL-8 and IL-33 in the diagnosis of severe asthma was 0.861,which was greater than the AUC of serum IL-8(0.660)and IL-33(0.681)alone(Z=2.579 and 1.978,P=0.023 and 0.047).Conclusion The serum levels of IL-8 and IL-33 in children with bronchial asthma related closely to the lung function indexes,and the combined detection of IL-8 and IL-33 has a high diagnostic value for severe bronchial asthma.