柴胡疏肝散加减联合梅花针治疗肝郁血瘀型斑秃的疗效及对焦虑、抑郁影响

Effect of Addition and Reduction of Chaihu Shugan Powder Combined with Plum Blossom Needle on Alopecia Areata with Liver Depression and Blood Stasis and its Influence on Anxiety and Depression

目的:对柴胡疏肝散加减联合梅花针治疗肝郁血瘀型斑秃的疗效及对焦虑、抑郁的影响进行探讨。方法:选取肝郁血瘀型斑秃患者49人,随机分为治疗组25人和对照组24人。2组在外用2%米诺地尔搽剂的基础上,治疗组予以口服柴胡疏肝散加减结合梅花针叩刺治疗,对照组采用口服复方甘草酸苷片治疗。2组疗程均为8周,观察并比较2组患者治疗前后的SALT评分、临床疗效、皮肤镜表现的变化以及对焦虑、抑郁情绪的影响。结果:2组SALT评分均较治疗前有所下降,且差异具有统计学意义(P<0.05),治疗组下降更为显著。两组患者疗效比较:治疗组有效率为88%,对照组有效率为62.5%,存在统计学差异(P<0.05)。皮肤镜下治疗组皮损形态与对照组相比较低,且差异具有统计学意义(P<0.05)。两组患者的焦虑、抑郁评分较治疗前都有所下降,相比对照组,治疗组患者的下降更为明显。差异在统计学上是有意义的(P<0.05)。结论:治疗肝郁血瘀型斑秃用柴胡疏肝散加减和梅花针联合施治,疗效确切,可改善焦虑、抑郁情绪。

Objective:To explore the efficacy of modified Chaihu Shugan Powder combined with Plum Blossom Acupuncture in treating alopecia areata due to liver stagnation and blood stasis and its effect on anxiety and depression.Methods:49 patients with liver stagnation and blood stasis type alopecia areata were selected and randomly divided into a treatment group of 25 people and a control group of 24 people.On the basis of topical 2%minoxidil liniment,the treatment group was treated with modified oral Chaihu Shugan Powder combined with plum blossom needle tapping,while the control group was treated with oral compound glycyrrhizin tablets.The treatment course of both groups was 8 weeks.The SALT scores,clinical efficacy,changes in dermoscopic manifestations and the impact on anxiety and depression were observed and compared between the two groups of patients before and after treatment.Results:The SALT scores of both groups decreased compared with before treatment,and the difference was statistically significant(P<0.05).The decrease in the treatment group was more significant.Comparison of the efficacy of the two groups of patients:the effective rate in the treatment group was 88%,and the effective rate in the control group was 62.5%,with a statistical difference(P<0.05).The skin lesion morphology of the treatment group under dermoscopy was lower than that of the control group,and the difference was statistically significant(P<0.05).The anxiety and depression scores of both groups of patients decreased compared with before treatment,and compared with the control group,the decrease in the treatment group was more obvious.The difference is statistically significant(P<0.05).Conclusion:A combination of modified Chaihu Shugan Powder and Plum Blossom Acupuncture is effective in treating alopecia areata with liver stagnation and blood stasis type,and can improve anxiety and depression.