养血益睛汤改善早期年龄相关性黄斑变性作用探究

Clinical Study of Traditional Chinese Medicine in the Treatment of Early Age-related Macular Degeneration

目的:探究养血益睛汤改善早期年龄相关性黄斑变性的作用及其对脉络膜的影响。方法:50例患者随机分为观察组和对照组,观察组25例采用口服中药养血益睛汤治疗,对照组25例予补充维生素C治疗。2组均治疗4周,观察2组患者视力恢复情况、2组治疗前后中心黄斑厚度及黄斑中心凹脉络膜厚度的变化及2组的临床疗效。结果:2组治疗后ETDRS字母数均优于治疗前(P<0.05),观察组治疗后ETDRS字母数及治疗前后ETDRS字母数差值均优于对照组(P<0.05);2组治疗后CMT及CMT差值均无统计学差异(P>0.05),2组治疗后SFCT均优于治疗前(P<0.05),2组间治疗后SFCT无统计学差异(P>0.05),观察组治疗前后SFCT差值优于对照组(P<0.05);观察组临床疗效优于对照组(P<0.05)。结论:中药养血益睛汤治疗早期AMD有良好的临床疗效,能改善患者的视觉质量、增加黄斑中心凹脉络膜的厚度。

Objective:To explore the effect of Yangxue Yiqing Decoction on improving early age-related macular degeneration and its effect on the choroid.Methods:50 patients were randomly divided into an observation group and a control group.25 patients in the observation group were treated with oral Chinese medicine Yangxue Yiqing Decoction,and 25 patients in the control group were treated with vitamin C supplementation.Both groups were treated for 4 weeks.The visual recovery of the patients in the two groups,the changes in the central macular thickness and foveal choroidal thickness before and after treatment in the two groups,and the clinical efficacy of the two groups were observed.Results:The number of ETDRS letters after treatment in both groups was better than before treatment(P<0.05).The number of letters in ETDRS after treatment and the difference in the number of letters in ETDRS before and after treatment in the observation group were both better than those in the control group(P<0.05);There was no statistical difference in CMT and CMT difference(P>0.05).The SFCT after treatment in both groups was better than before treatment(P<0.05).There was no statistical difference in SFCT after treatment between the 2 groups(P>0.05).The observation group The SFCT difference before and after treatment was better than that of the control group(P<0.05);the clinical efficacy of the observation group was better than that of the control group(P<0.05).Conclusion:The traditional Chinese medicine Yangxue Yiqing Decoction has good clinical efficacy in treating early AMD.It can improve the visual quality of patients and increase the thickness of the choroidal fovea.