Wnt/β-catenin信号通路在肺纤维化中的作用及中医药调控研究进展

The role of Wnt/β-catenin Signaling Pathway in Pulmonary Fibrosis and its Regulation by Traditional Chinese Medicine

肺纤维化(Pulmonary fibrosis,PF)是一种致命且不可逆的呼吸系统疾病,在间质性肺疾病终末期过度表现,以肺泡上皮细胞损伤及异常修复、成纤维细胞增殖、细胞外基质过度沉积等为病理特征,对人类健康造成严重危害,已成为威胁世界范围的公共卫生问题。Wnt/β-连环蛋白(Wnt/β-catenin)信号通路是PF经典通路之一,能够直接或间接参与细胞增殖、炎症细胞浸润、肺组织血管新生及上皮间质转化(EMT)等。中医药在防治PF方面已取得不错的效果,其中有不少中药复方及单体或有效成分通过靶向调节Wnt/β-catenin信号通路作用于PF,文章对近年来中医药调控Wnt/β-catenin信号通路治疗PF相关研究成果进行综述,以期为中医药临床应用提供合理选择。

Pulmonary fibrosis(PF)is a fatal and irreversible respiratory disease that manifests excessively in the end-stage of interstitial lung disease and is characterized by damage and abnormal repair of alveolar epithelial cells,fibroblast proliferation,and excess extracellular matrix.Deposition and other pathological characteristics cause serious harm to human health and have become a public health problem threatening the world.The Wnt/β-catenin signaling pathway is one of the classic pathways of PF and can directly or indirectly participate in cell proliferation,inflammatory cell infiltration,lung tissue angiogenesis,epithelial-mesenchymal transition(EMT),etc.Traditional Chinese medicine has achieved good results in the prevention and treatment of PF.Many traditional Chinese medicine compounds,monomers or active ingredients act on PF by targeting the Wnt/β-catenin signaling pathway.This article reviews the regulation of Wnt/β-catenin by traditional Chinese medicine in recent years.This article reviews the research results related to the catenin signaling pathway in the treatment of PF,in order to provide a reasonable choice for the clinical application of traditional Chinese medicine.