铁死亡对骨肉瘤作用机制的研究进展

Research progress on the mechanism of ferroptosis on osteosarcoma

骨肉瘤是幼儿和青年中最常见的骨恶性肿瘤疾病,其通常有很强的侵袭性,常规的治疗无法达到预期的效果,因此研究肿瘤细胞死亡机制并探索更有效的治疗方法具有重要意义。铁死亡作为一种新型细胞死亡形式,已经发现有三种主要调控通路,并与肿瘤细胞分子机制、基因等息息相关,这对铁死亡在骨肉瘤治疗中的应用提供了理论依据。本文对近年来关于铁死亡与骨肉瘤在调控分子、基因等相互作用的研究,以及铁死亡在骨肉瘤治疗中的应用进行综述。

Osteosarcoma is the most common malignant bone tumor disease in young children and young people.It usually has strong invasiveness,and conventional treatment cannot achieve the expected results.Therefore,studying the mechanism of tumor cell death and exploring more effective treatment methods is of great significance.As a new form of cell death,ferroptosis has been found to have three main regulatory pathways closely related to tumor cell molecular mechanisms,genes,etc.This provides a theoretical basis for the application of ferroptosis in the treatment of osteosarcoma.This article reviews recent research on the interaction between ferroptosis and osteosarcoma in regulating molecules,genes,and other factors,as well as the application of ferroptosis in the treatment of osteosarcoma.