SENP1/HIF-1α调控牙髓干细胞成血管分化的研究进展

Research progress on SENP1/HIF-1α regulation of vascular differentiation of dental pulp stem cells

牙髓干细胞(DPSC)是从牙髓中分离的、具有高分化潜能的多能干细胞,通过DPSC进行血管再生也许是一个不错的选择。缺氧诱导因子-1α(HIF-1α)是血管内皮生长因子(VEGF)的上游基因,小泛素修饰物蛋白酶1(SENP1)能够逆转HIF-1α的小泛素样(SUMO)修饰。通过SENP1/HIF-1α的调控,在许多体内外实验中都表现出了良好的血管再生特性。SENP1/HIF-1α信号轴对许多实体肿瘤有着不同程度的促进及抑制作用,目前虽然SENP1/HIF-1α信号轴在牙髓干细胞内作用的相关文献相对较少,但能够确定SENP1/HIF-1α对牙髓干细胞的血管生成方面起到重要作用。本文将阐述SENP1/HIF-1α信号通路,及其促进DPSC成血管分化的作用机制。

Dental pulp stem cells(DPSC)are pluripotent stem cells with high differentiation potential isolated from dental pulp.Using DPSC for vascular regeneration may be a good option.Hypoxia inducible factor-1α(HIF-1α)is an upstream gene of vascular endothelial growth factor(VEGF),and the small ubiquitin like protease 1(SENP1)can reverse the small ubiquitin like(SUMO)modification of HIF-1α.Through the regulation of SENP1/HIF-1α,good vascular regeneration characteristics have been demonstrated in many in vitro and in vivo experiments.The SENP1/HIF-1α signaling axis has varying degrees of promoting and inhibiting effects on many solid tumors.Although there is relatively little literature on the role of the SENP1/HIF-1α signaling axis in dental pulp stem cells,it can be determined that SENP1/HIF-1α plays an important role in the angiogenesis of dental pulp stem cells.This article will elucidate the SENP1/HIF-1α signaling pathway and its mechanism of promoting vascular differentiation of DPSC.