中国老年糖尿病人群合并周围神经病变危险因素Meta分析

Meta-analysis of risk factors for peripheral neuropathy in elderly Chinese diabetic population

目的:探讨中国老年糖尿病人群合并周围神经病变的主要危险因素。方法:计算机检索中国知网、万方、维普、中国生物医学文献数据库(CBM)、PubMed、Web of Science、EMbase、Cochrane Library数据库中关于中国老年糖尿病人群合并周围神经病变危险因素的相关文献,检索时限为建库至2022年10月11日。采用Stata 12.0进行Meta分析。结果:共纳入12篇文献,包括老年糖尿病患者合计3492例,合并周围神经病变患者2057例。Meta分析显示,中国老年糖尿病合并周围神经病变的危险因素包括年龄[OR=1.194,95%CI(1.111,1.283),P<0.05]、病程[OR=1.756,95%CI(1.497,2.060),P<0.05]、糖化血红蛋白(HbAlc)[OR=1.516,95%CI(1.244,1.848),P<0.05]、总胆固醇(TC)[OR=1.323,95%CI(1.079,1.622),P<0.05]、餐后2 h血糖[OR=1.108,95%CI(1.056,1.163),P<0.05]。结论:影响中国老年糖尿病患者合并周围神经病变的危险因素有年龄、糖尿病病程、糖化血红蛋白、总胆固醇和餐后2 h血糖,应从多个方面进行预防控制。

Objective:To investigate the main risk factors of peripheral neuropathy in elderly Chinese patients with diabetes mellitus.Methods:Literature on risk factors of peripheral neuropathy in elderly Chinese patients with diabetes was searched from CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,EMbase and Cochrane Library.The search time limit was from the establishment of the database to October 11,2022.The Stata12.0 software was used during the meta-analysis.Results:In all,12 studies were included,including 3492 elderly patients with diabetes and 2057 patients with peripheral neuropathy.Meta-analysis indicated that risk factors for peripheral neuropathy in older Chinese patients with diabetes comprised age[OR=1.194,95%CI(1.111,1.283),P<0.05],course of disease[OR=1.756,95%CI(1.497,2.060),P<0.05],HbAlc[OR=1.516,95%CI(1.244,1.848),P<0.05],TC[OR=1.323,95%CI(1.079,1.622),P<0.05],and 2hPG[OR=1.108,95%CI(1.056,1.163),P<0.05].Conclusion:Age,duration of diabetes,glycosylated hemoglobin,total cholesterol and blood sugar two hours after a meal are the risk factors of peripheral neuropathy in elderly patients with diabetes in China,which should be prevented and controlled from multiple aspects.