枳实大黄汤联合丁苯酞对急性脑梗死神经功能和氧化应激的影响

Influence of Zhishi Dahuang Decoction Combined with Butyphthalide on Neurological Function and Serum Oxidative Stress in Acute Cerebral Infarction

目的观察枳实大黄汤联合丁苯酞对急性脑梗死(ACI)患者的神经功能及血清氧化应激水平的影响。方法将92例ACI患者按照随机数字表法分为两组各46例,观察组采用枳实大黄汤联合丁苯酞治疗,对照组采用丁苯酞治疗,治疗周期14 d。观察治疗后两组临床疗效、中医证候评分、神经功能、血清氧化应激水平以及不良反应。结果治疗14 d后,观察组血清丙二醛(MDA)、一氧化氮(NO)水平低于对照组(P<0.05),超氧化物歧化酶(SOD)水平高于对照组(P<0.05)。治疗后两组神经功能评分均明显下降(P<0.05),观察组治疗后评分均显著低于对照组(P<0.05)。观察组总有效率为95.65%,高于对照组78.26%(P<0.05)。治疗后观察组半身不遂、偏身麻木、头晕目眩等症状积分均低于对照组(P<0.05);观察组胃肠道障碍、肢体乏力、言语不清、反应迟钝等不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论枳实大黄汤联合丁苯酞治疗ACI患者能够改善血清氧化应激水平,提升神经功能,提高其临床疗效,改善临床症状,无明显不良反应。

Objective:To observe the influence of Zhishi Dahuang Decoction combined with butyphthalide on neurological function and serum oxidative stress level in patients with acute cerebral infarction(ACI).Methods:A total of 92 ACI patients were randomly divided into an observation group(treated with Zhishi Dahuang Decoction combined with butylphthalide)of 46 cases and a control group(treated with butylphthalide)of 46 cases,with a treatment period of 14 days.The clinical efficacy,traditional Chinese medicine symptom scores,neurological function,serum oxidative stress levels,and adverse reactions after treatment were observed.Results:After 14 days of treatment,the levels of serum malondialdehyde(MDA)and nitric oxide(NO)in the observation group were lower than those in the control group(P<0.05),and the levels of superoxide dismutase(SOD)were higher than those in the control group(P<0.05).After treatment,there were statistically significant differences in neurological function scores between the two groups at different time points and interactions(P<0.05).The observation group had significantly lower scores than the control group after treatment(P<0.05).After treatment,the total effective rate in the observation group was 95.65%,which was higher than 78.26%in the control group(P<0.05).After treatment,the observation group had lower scores for symptoms such as hemiplegia,hemianesthesia and dizziness than the control group(P<0.05).After treatment,the incidence of adverse reactions such as gastrointestinal disorders,limb fatigue,unclear speech,and delayed response in the observation group was no different from that in the control group(P>0.05).Conclusion:The combination of Zhishi Dahuang Decoction and butylphthalide in the treatment of ACI patients can improve serum oxidative stress levels,enhance neurological function,enhance clinical efficacy,improve clinical symptoms,and have no obvious adverse reactions.