类风湿性关节炎患者血清ASC NLRP3水平及意义

Serum ASC and NLRP3 Levels and Their Significance in Patients with Rheumatoid Arthritis

目的:探讨血清人细胞凋亡相关斑点样蛋白(ASC)、NOD样受体热蛋白结构域相关蛋白3(NLRP3)对类风湿性关节炎(RA)患者的预测价值。方法:选取2021年11月至2023年6月我院收治88例类风湿性关节炎患者作为RA组、同期88例健康体检者为对照组。采用酶联免疫吸附法检测血清ASC和NLRP3水平。采用Spearman相关性分析类风湿性关节炎患者血清ASC、NLRP3水平与DAS28评分的相关性,采用Logistic回归分析类风湿性关节炎患者的影响因素。结果:RA组血清ASC水平高于健康对照组,NLRP3水平高于健康对照组,差异有统计学意义(P<0.05)。Logistic回归分析显示,ASC、NLRP3为RA患者独立危险因素(P<0.05)。结论:血清ASC和NLRP3水平升高与DAS28评分独立相关,血清ASC、NLRP3对RA及其疾病活动度有潜在的诊断价值。

Objective:To investigate the predictive value of serum human apoptosis-associated speck-like protein(ASC)and NOD-like receptor heat protein structural domain-related protein 3(NLRP3)in rheumatoid arthritis(RA)patients.Methods:A total of 88 patients with RA diagnosed at our hospital from November 2021 to June 2023 were enrolled as the RA group,and 88 healthy volunteers were enrolled as the control group.Serum ASC and NLRP3 levels were measured by enzyme-linked immunosorbent assay.Spearman correlation analysis was used to analyze the correlation between serum ASC,NLRP3 levels and DAS28 scores in patients with RA,and logistic regression analysis was used to analyze the influencing factors of RA.Results:The serum ASC levels in the RA group were significantly higher than those in the healthy control group,and the NLRP3 levels were significantly higher than those in the healthy control group,with statistical significance(P<0.05).Logistic regression analysis showed that ASC and NLRP3 were independent risk factors for RA patients(P<0.05).Conclusion:The increased serum ASC and NLRP3 levels are independently correlated with DAS28 scores,suggesting that serum ASC and NLRP3 have potential diagnostic value for RA and its disease activity.