盐酸甲氯芬酯胶囊联合醒脾养儿颗粒治疗小儿遗尿的临床疗效观察

Clinical Observation of Xingpi Yanger Combined with Meclofenoxate Hydrochloride Capsule in Treating Infantile Enuresis

目的:分析盐酸甲氯芬酯胶囊联合醒脾养儿颗粒治疗小儿遗尿症的临床效果,为临床推广提供科学依据。方法:选取于2020年5月至2022年7月我院收治的小儿遗尿患儿共148例,按照随机数法并根据治疗方法不同将入组患儿分为研究组和对照组,每组各74例。对照组给予口服盐酸甲氯芬酯胶囊治疗,研究组给予口服盐酸甲氯芬酯胶囊+醒脾养儿颗粒治疗,连续治疗4周。评价两组临床疗效并对比两组患儿治疗前后中医症候积分、遗尿次数、睡眠觉醒障碍评分、唤醒阈、膀胱容量以及尿渗透压和抗利尿激素(ADH)水平。记录治疗后3个月内两组患儿复发率。结果:研究组治疗总有效率(85.14%)高于对照组(64.86%);治疗后两组中医症候积分、两组遗尿次数、睡眠觉醒障碍评分以及唤醒阈指标均降低,且研究组低于对照组;治疗后两组膀胱容量、尿渗透压和ADH的浓度水平均增加,且研究组高于对照组,上述差异均有统计学意义(P<0.05)。随访3月,研究组复发率(8.11%)低于对照组(20.27%),该差异有统计学意义(P<0.05)。结论:醒脾养儿联合盐酸甲氯芬酯胶囊可以显著改善小儿遗尿的临床疗效并降低复发率,值得临床推广。

Objective:To explore the clinical efficacy of Xingpi Yanger combined with Meclofenoxate Hydrochloride Capsules in the treatment of enuresis in children.Methods:148 children with enuresis in our hospital from May 2020 to July 2022 were randomly divided into control group(n=74)and investigation group(n=74)according to random number method.The control group was treated with oral meclofenoxate hydrochloride capsules,and the investigation group was treated with oral meclofenoxate hydrochloride capsules+Xingpi Yanger granules for 4 weeks.To evaluate the clinical efficacy of the two groups and compare the TCM symptom score,enuresis times,sleep awakening disorder score,awakening threshold,bladder capacity,urine osmotic pressure and antidiuretic hormone(ADH)levels before and after treatment in the two groups.The recurrence situation was recorded within 3 months-treatment.Results:The overall response rate of investigation group was 85.14%,higher than control group with 64.86%;After treatment,the TCM symptom score,enuresis frequency,sleep awakening disorder score and awakening threshold index of the two groups were decreased,and the investigation group was lower than the control group;Bladder capacity,urine osmolality,and concentration levels of ADH increased in both groups after treatment,and were higher in the investigation group than in the control group,all these differences were statistically significant(P<0.05).After a follow-up of 3 months,the recurrence rate in study group(8.11%)was statistically lower than that in control group(20.27%).Conclusion:Xingpi Yanger combined with meclofenoxate hydrochloride capsules can significantly improve the clinical efficacy of enuresis in children and reduce the recurrence rate,which is worthy of clinical promotion.