摘要
目的为中医临床治疗肌萎缩侧索硬化症(ALS)提供参考。方法计算机检索中国知网中以中药治疗ALS的个案文献,检索时限为自建库起至2022年11月。采用Excel软件统计复方中组方药物的使用频次(率)、四气(性)、五味、归经、功效,并导入中医传承计算平台(V 3.0)进行数据挖掘。结果共纳入个案文献110篇,涉及中药组方139个、中药218味,累计使用频次1946次。常用药物(使用频率>10%)45味,性味归经分别以温性(47.35%)、甘味(42.45%)、归脾经(20.29%)为主,药物功效以补虚类(41.37%)为主。中药组合98个,涉及中药24味,其中以黄芪、白术、党参组合(33次)最常见,药对以黄芪-山药、黄芪-熟地黄最常见(均使用32次);聚类分析提取核心药物组合5类。结论ALS个案用药处方以补虚类中药为核心,分补气、补血、补阳、补肝肾,配以升阳、温里、行气等药味。处方组合以气血双补、阴阳双补、清热化痰和益气活血为主要功效。
Objective To provide a reference for the clinical treatment of amyotrophic lateral sclerosis(ALS)with traditional Chinese medicine.Methods Case reports of Chinese materia medica in the treatment of ALS in the CNKI from the inception of this database to November 2022 were searched.The medicinal frequency of use,nature,flavor,meridian returned and efficacy in prescriptions were recorded by the Excel software and imported into the Traditional Chinese Medicine Inheritance Computer System(V 3.0)for data mining.Results A total of 110 case reports were included,involving 139 prescriptions and 218 Chinese materia medicas,with the cumulative use frequency of 1946 times.Forty-five Chinese materia medicas were commonly used,with a frequency of use>10%,the nature,flavor and meridian returned was mainly warm(47.35%),sweet(42.45%)and spleen meridian(20.29%),and the efficacy was mainly tonifying deficiency(41.37%).There were 98 drug combinations,involving 24 Chinese materia medicas,mainly Astragali Radix-Atractylodis Macrocephalae Rhizoma-Codonopsis Radix(33 times),with the main drug pairs of Astragali Radix-Dioscoreae Rhizoma(32 times)and Astragali Radix-Rehmanniae Radix Praeparata(32 times).The cluster analysis showed that five core drug combinations were extracted.Conclusion The deficiency-tonifying drugs are the core in the medication prescriptions for ALS in case reports,including Qi-,blood-,Yang-,liver-and kidney-tonifying drugs,and they are supplemented with Yang-lifting,interior-warming and Qi-moving drugs.The prescription combination are mainly based on the principles of tonifying Qi and blood,tonifying Yin and Yang,clearing heat and dissipating phlegm,and benefiting Qi and activating blood.
作者
滕羽鸥
朱顺
李婷
倪敬年
魏明清
时晶
TENG Yuou;ZHU Shun;LI Ting;NI Jingnian;WEI Mingqing;SHI Jing(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China 100700)
出处
《中国药业》
CAS
2024年第4期53-57,共5页
China Pharmaceuticals
基金
中国工程院战略研究与咨询项目[2022-XY-33,2022-XBZD-15-04]
北京中医药大学基本科研业务费项目[2023-JYB-KYPT-04]
北京中医药大学“解码中医”协同攻关项目[BZY-JMZY-2022-002]。
关键词
肌萎缩侧索硬化
中医传承计算平台
个案
补虚
中药
用药规律
amyotrophic lateral sclerosis
Traditional Chinese Medicine Inheritance Computer System
case report
tonifying deficiency
Chinese materia medica
medication rule