颈动脉超声相关参数与冠脉粥样硬化病变程度的相关性

Correlation between related carotid ultrasound parameters and severity of coronary atherosclerosis

目的:研究颈动脉超声相关参数与冠脉粥样硬化病变程度的相关性。方法:依据冠脉病变支数,于我院行冠脉造影确诊的116例冠心病患者被分为单支病变组(38例)、双支病变组(39例)与≥3支病变组(39例),选择同期健康体检者41例作为健康对照组。比较各组一般临床资料、颈动脉超声参数,并分析其与冠脉粥样硬化病变程度的相关性。结果:与健康对照组比较,单支病变组、双支病变组、≥3支病变组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平、颈动脉内膜-中层厚度(IMT)、Crouse积分均显著升高,双支病变组、≥3支病变组斑块回声灰阶中位数(GSM)均显著降低;与单支病变组比较,双支病变组、≥3支病变组TG、LDL-C水平、Gensini积分、Crouse积分及≥3支病变组TC水平均显著升高,≥3支病变组斑块回声GSM显著降低;与双支病变组比较,≥3支病变组TC水平、Gensini积分、Crouse积分均显著升高,斑块回声GSM显著降低(P<0.05或<0.01)。Pearson相关性分析显示,冠心病患者Gensini积分与Crouse积分呈显著正相关(r=0.580,P=0.001);Spearman相关性分析显示,IMT与冠脉病变支数呈显著正相关(r=0.582,P=0.001),斑块回声GSM与其呈显著负相关(r=-0.518,P=0.001)。结论:颈动脉超声相关参数与冠脉粥样硬化病变程度呈显著相关性。

Objective:To study correlation between related carotid ultrasound parameters and severity of coronary atherosclerosis(AS).Methods:According to number of diseased coronary arteries,a total of 116 patients with coronary heart disease diagnosed by coronary angiography in our hospital were divided into single vessel coronary disease group(n=38,single group),double vessel coronary disease group(n=39,double group)and≥3 vessel coronary disease group(n=39,multiple group).Another 41 healthy subjects were simultaneously regarded as healthy control group.General clinical data and carotid ultrasound parameters were compared among all groups,and correlation among them and AS severity was analyzed.Results:Compared with healthy control group,there were significant rise in levels of total cholesterol(TC),triglycerides(TG)and low density lipoprotein cholesterol(LDL-C),carotid intima-media thickness(IMT)and Crouse score in single,double and multiple groups,and significant reductions in plaque echo gray-scale median(GSM)in double and multiple groups.Compared with single group,there were significant rise in levels of TG and LDL-C,Gensini score and Crouse score in double and multiple groups and TC level in multiple group,and significant reduction in plaque echo GSM in multiple group.Compared with double group,there were significant rise in TC level,Gensini score and Crouse score,and significant reduction in plaque echo GSM in multiple group(P<0.05 or<0.01).Pearson correlation analysis indicated that Gensini score was significant positively correlated with Crouse score in these patients(r=0.580,P=0.001).Spearman correlation analysis indicated that IMT was significant positively correlated with number of diseased coronary arteries(r=0.582,P=0.001),and plaque echo GSM was significant inversely correlated with it(r=-0.518,P=0.001)in these patients.Conclusion:Related carotid ultrasound parameters are significantly correlated with severity of coronary atherosclerosis.