几种常见镇静镇痛药对缺血性心脏病患者心血管保护作用机制的研究进展

Research progress on the mechanism of several common sedatives and analgesics on cardiovascular protection in patients with ischemic heart disease

目前人们的生活水平不断提高,但经济发展的同时也带来了生活习惯上的变化,不良饮食使心血管疾病的发生率逐年增加,我国每年缺血性心脏病患者人数居高不下,其起病急骤、病情变化快、病死率高的特点对很多家庭造成极大打击。现代医学的发展使缺血性心脏病患者手术风险大大降低,但想要在保证患者安全的前提下顺利完成手术,仍需要掌握和理解镇静镇痛药物对心血管的影响作用。丙泊酚、七氟烷、舒芬太尼、瑞芬太尼和右美托咪定是较为常用的镇静镇痛药,本文就以上药物对心血管保护作用的机制进行综述。

Currently,living standard of people keeps growing,however,living habit changes follow economic development.Poor diet makes incidence rate of cardiovascular diseases increase year by year.Number of patients suffering from ischemic heart disease remains high in China every year,its characteristics of sudden onset,rapidly changing condition and high mortality bring huge shock on many families.The development of modern medicine has greatly reduced the risk of surgery for patients with ischemic heart disease(IHD).However,it is still necessary to master and understand the effects of sedatives and analgesics on cardiovascular system in order to perform successful completion of surgery on the premise of patient safety.Propofol,sevoflurane,sufentanil,remifentanil and dexmedetomidine are commonly used sedatives and analgesics.The present article makes a review on the mechanism of above drugs on cardiovascular protection.