中性粒细胞胞外诱捕网在病毒性心肌炎中的作用

Role of neutrophil extracellular traps in viral myocarditis

病毒性心肌炎(VMC)是临床常见的心血管疾病,炎症免疫应答是VMC的主要发病病因。中性粒细胞作为先天免疫应答的一部分在VMC中发挥的作用过去很少被研究。然而多个研究表明,中性粒细胞可通过一种新的防御机制即中性粒细胞胞外诱捕网(NETs)的形成参与多种疾病。并且,最近在活动性心肌炎患者和VMC模型心肌病理活检中都发现有NETs形成,因此NETs被推测在VMC发病过程中发挥一定作用。本文就NETs在VMC中的作用作一综述。

Viral myocarditis(VMC)is a common clinical cardiovascular disease,and inflammatory immune response is the main cause of VMC.Role that neutrophils play in VMC as a part of innate immune response has rarely been studied in the past.However,several studies have indicated that neutrophils can be involved in a variety of diseases through formation of a new defense mechanism called neutrophil extracellular traps(NETs).Moreover,NETs formation has been recently discovered in patients with active myocarditis and in myocardial pathological biopsies of VMC model,thus NETs are presumed to play a certain role in pathogenesis of VMC.The present article makes a review on role of NETs in VMC.