益气通络安神方联合他汀类药物治疗冠心病合并高血压病对患者冠状动脉血流及血压的影响

Effect of Yiqi Tongluo Anshen Recipe combined with statins on coronary blood flow and blood pressure in patients with coronary heart disease and hypertension

目的探讨益气通络安神方联合他汀类药物治疗冠心病合并高血压病对患者冠状动脉血流及血压的影响。方法选取冠心病合并高血压病患者120例为研究对象,根据治疗方法的不同分为2组,每组60例。常规组给予氨氯地平片联合阿托伐他汀钙片治疗,安神方组在常规组基础上给予益气通络安神方治疗。记录2组治疗前后心血管调节肽(Salusin-β)、脂蛋白相关磷脂酶A2(LP-PLA2)、超敏C反应蛋白(hs-CRP)、五聚素3(PTX3)、肿瘤坏死因子-α(TNF-α)水平及血压的变化情况,并统计2组心肌梗死溶栓试验(TIMI)冠状动脉血流TIMI3级率和治疗期间的不良反应发生率。结果安神方组中医证候总有效率高于常规组,差异有统计学意义(P<0.05)。治疗后,2组收缩压(SBP)、舒张压(DBP)较治疗前下降,且安神方组治疗后SBP、DBP低于常规组,差异有统计学意义(P<0.05)。安神方组冠状动脉血流TIMI3级率高于常规组,差异有统计学意义(P<0.05)。治疗后,2组Salusin-β、LP-PLA2、PTX3、hs-CRP、TNF-α水平较治疗前下降,且安神方组治疗后Salusin-β、LP-PLA2、PTX3、hs-CRP、TNF-α水平低于常规组,差异有统计学意义(P<0.05)。安神方组与常规组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论益气通络安神方联合他汀类药物治疗冠心病合并高血压病可降低患者体内相关因子的表达,改善冠状动脉血流,提高临床疗效。

Objective To explore the effect of Yiqi Tongluo Anshen Recipe combined with statins on coronary blood flow and blood pressure in patients with coronary heart disease complicated with hypertension.Methods A total of 120 patients with coronary heart disease combined with hypertension were selected as study objects,and were divided into two groups according to treatment methods,with 60 patients in each group.The conventional group was treated with amlodipine tablets combined with atorvastatin calcium tablets,and the Anshen prescription group was treated with Yiqi Tongluo Anshen Recipe on the basis of the conventional group.The levels of Salusin-β,lipoprotein-associated phospholipase A2(LP-PLA2),high-sensitivity C-reactive protein(hs-CRP),pentamylin 3(PTX3),tumor necrosis factor-α(TNF-α)and blood pressure of the two groups were recorded before and after treatment,and the TIMI3 rate of coronary blood flow in myocardial infarction thrombolysis test(TIMI)and the adverse reaction rate during treatment were analyzed.Results The total effective rate of TCM syndrome in the Anshen prescription group was higher than that in conventional group(P<0.05).After treatment,systolic blood pressure(SBP)and diastolic blood pressure(DBP)in two groups were lower than before treatment,and SBP and DBP in the Anshen prescription group were lower than those in the conventional group(P<0.05).The rate of coronary blood flow TIMI3 in the Anshen prescription group was higher than that in the conventional group(P<0.05).After treatment,levels of Salusin-β,LP-PLA2,PTX3,hs-CRP and TNF-αin two groups were decreased compared with those before treatment,and levels of Salusin-β,LP-PLA2,PTX3,hs-CRP and TNF-αlevels of in the Anshen prescription group after treatment were lower than those in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the Anshen prescription group and the conventional group(P>0.05).Conclusion Yiqi Tongluo Anshen Recipe combined with statins in the treatment of coronary heart disease with hypertension can reduce the expression of related factors,improve coronary blood flow and the curative effect.