铜代谢在癌症治疗中的作用综述

Review of role of copper metabolism in the treatment of cancer

铜是人体必需的微量元素,参与大量细胞机制和信号通路,依靠其氧化还原活性来协调多种生物活性。如果细胞内的铜超过细胞本身的需求,或者在细胞内分配不当,则会产生细胞毒性,许多癌症都表现出铜的增加。铜可以通过促进细胞增殖、血管形成与细胞转移,进而参与癌症的发展与扩散。铜螯合剂与铜离子载体是将铜浓度保持在生理水平的有效手段。本文综述了铜在细胞内的调控以及铜与铜结合蛋白在癌症发生发展中的作用,讨论使用铜衍生物作为抗癌剂的治疗进展。

Copper is an essential trace element in the human body,which participates in numerous cellular mechanisms and signaling pathways,and various biological activities need to be coordinated through redox activity of copper.If the amount of copper in the cell exceeds the cell's own needs or is improperly distributed within the cell,the cellular toxicity will occur,and many cancers will be characterized by increasing of copper.Copper can participate in the development and spread of cancer by promoting cell proliferation,angiogenesis,and cell metastasis.Copper chelators and copper ion carriers are effective means of maintaining copper concentration at physiological levels.This paper reviewed the regulation of copper in cells and the role of copper and copper binding proteins in the occurrence and development of cancer,and discussed the therapeutic progress of using copper derivatives as anticancer agents.