明目羊肝丸联合重组人表皮生长因子滴眼液对白内障患者术后角膜水肿和炎症因子的影响

Effect of Mingmu Yanggan Pills combined with Recombinant Human Epidermal Growth Factor Eye Drops on postoperative corneal edema and inflammatory factors in patients with cataract

目的 探讨明目羊肝丸联合重组人表皮生长因子(rhEGF)滴眼液对白内障患者术后角膜水肿和炎症因子的影响。方法 将80例白内障术后角膜水肿患者随机分为观察组39例(47眼)和对照组41例(47眼)。给予对照组rhEGF滴眼液治疗,观察组在对照组的基础上加用明目羊肝丸口服,两组均治疗4周。比较两组临床疗效、角膜水肿消退时间,以及治疗前后视力、泪膜稳定性[泪膜破裂时间(BUT)、泪液分泌试验(SIT)滤纸浸湿长度]、血清炎症因子[白细胞介素(IL)-6、IL-8、肿瘤坏死因子α(TNF-α)]水平,记录治疗期间不良反应发生情况。结果 观察组显效率高于对照组,患眼角膜水肿消退时间短于对照组(P<0.05)。治疗后,观察组视力、BUT及SIT滤纸浸湿长度高于或长于治疗前及对照组,而血清IL-6、IL-8、TNF-α水平低于治疗前及对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 明目羊肝丸联合rhEGF滴眼液治疗可更快速缓解白内障患者术后角膜水肿,改善视力及泪膜稳定性,减轻炎症反应,效果优于单一rhEGF滴眼液治疗,且安全性较好。

Objective To explore the effect of Mingmu Yanggan Pills combined with Recombinant Human Epidermal Growth Factor(rhEGF) Eye Drops on postoperative corneal edema and inflammatory factors in patients with cataract.Methods Eighty patients with corneal edema after cataract surgery were randomly divided into observation group(39 cases,47 eyes) or control group(41 cases,47 eyes).The control group was treated with rhEGF Eye Drops,based on which the observation group was orally administrated Mingmu Yanggan Pills additionally.Both groups received treatment for 4 weeks.The clinical efficacy,corneal edema resolution time,and pre-and post-treatment visual acuity,stability of tear film(breakup time of tear film [BUT],Schirmer test [SIT] filter paper soaking length),and serum inflammatory factors(interleukin [IL]-6,IL-8,tumor necrosis factor α [TNF-α]) levels were compared between the two groups.The occurrence of adverse reactions of the two groups was recorded.Results The effective rate of the observation group was higher than that of the control group,and corneal edema resolution time of affected eye in the observation group was shorter than that in the control group(P<0.05).After treatment,the observation group yielded higher visual acuity,longer BUT and SIT filter paper soaking length as compared with before treatment and the control group,whereas lower levels of serum IL-6,IL-8,TNF-α as compared with before treatment and the control group(P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Mingmu Yanggan Pills combined with rhEGF Eye Drops can more accelerate relief of postoperative corneal edema in cataract patients,ameliorate visual acuity and tear film stability,alleviate inflammatory responses,exerting superior effects to single rhEGF Eye Drops therapy,with a relatively favorable safety.