2023年慢性阻塞性肺疾病全球倡议更新评述

Review of updates 2023 global initiative for chronic obstructive pulmonary disease

慢性阻塞性肺病(COPD)发病机制复杂,是一种复杂累积和动态的基因-环境-时间相互作用的最终结果,这些相互作用会损害肺部和/或改变其正常的发育。COPD目前是全球范围内发病率和死亡率的主要原因,其经济和社会负担正在不断增加。本文根据2023年慢性阻塞性肺疾病全球倡议(GOLD)的更新,就COPD定义、诊断和治疗等关键问题进行评述,以期为临床医师诊断和治疗COPD患者提供参考和借鉴。

Chronic obstructive pulmonary disease(COPD),a chronic disease with complicated pathogenesis,is the end-result of complex,cumulative and dynamic Gene-Environment-Time interactions over the lifetime that can damage the lung and/or alter normal development.COPD is a leading cause of morbidity and mortality worldwide,accounting for heavy economic and social burden which are continuously increasing.In order to provide clinical references for its diagnosis and treatment,this article reviewed the key issues of COPD,including definition,diagnosis,and therapy,which are based on the update of 2023 Global Initiative for Chronic Obstructive Lung Disease(GOLD).