卵母细胞发育的代谢调控

Metabolic control of oocyte development

有序均衡的代谢活动对卵母细胞发育至关重要.早期的研究多集中于影响卵母细胞成熟的外源性营养素,而很少关注细胞内的代谢酶与代谢物.因此,全面解析代谢模式特征有助于阐明卵母细胞发育的分子调控机制.近年来,关于细胞代谢与表观遗传修饰之间的密切联系被广泛报道;此外,母源环境改变所导致的卵母细胞代谢紊乱,可能会通过表观修饰影响早期胚胎发育及子代健康.本文将对卵母细胞成熟过程中代谢调控的研究进展进行综述,并从卵子表观修饰角度探讨母源环境异常影响子代健康的潜在机制,以期提高卵母细胞质量,改善女性生殖健康.

Well balanced and timed metabolism is essential for oocyte development.The effects of extrinsic nutrients on oocyte maturation have been widely reported,but intrinsic control of oogenesis by intracellular metabolites and metabolic enzymes has received little attention.The comprehensive characterization of metabolic patterns could lead to more complete understanding of regulatory mechanisms underlying oocyte development.Recently the close contact between cellular metabolism and epigenetic modifications has been widely reported.In addition,oocytes metabolic disorders caused by changes in the maternal environment may affect early embryonic development and offspring health through epigenetic modifications.Here we summarize the findings on metabolic regulation in oocyte maturation.And we discuss the potential mechanisms of maternal environmental abnormalities affecting offspring health from the perspective of oocyte epigenetic modification,with a view to improving oocyte quality and female reproduction.