高能量饮食及肥胖影响男性生育力的研究进展

Research progress on the association of high-energy diet and obesity with male infertility

饮食对人体正常生理活动有重要影响.高能量饮食和肥胖对男性生殖健康的潜在有害影响一直备受关注.多项研究表明,高能量饮食和肥胖通过直接或/和间接的途径影响男性生殖轴、精液质量、肠道菌群和睾丸微环境等,在男性不育的发生中发挥重要的作用.父系肥胖不仅影响自身健康,也可通过精子的表观遗传调控作用对子代造成影响.同时,改善饮食结构和采取适当的减重措施可以在一定程度上逆转高能量饮食和肥胖对男性生育力造成不利影响.本文旨在综述目前关于高能量饮食和肥胖与男性生育力之间的研究进展,探讨其导致男性不育的内在机制,探寻其潜在的干预措施,以提高男性生殖健康的水平,具有重要的临床价值.

The implications of high-energy diet and obesity on male infertility have garnered significant attention.Numerous studies have emphasized the pivotal roles of high-energy diet and obesity in male infertility,impacting the male reproductive axis,semen quality,gut microbiota,and testicular microenvironment.Paternal obesity affects the health of the offspring through epigenetic modifications in sperm.Nonetheless,improving dietary structure and implementing appropriate weight loss measures can partially alleviate the adverse effects of high-energy diet and obesity on male infertility.This review aims to summarize the current research progress on the relationship between high-energy diet,obesity,and male infertility;investigate the underlying mechanisms leading to male infertility,and explore potential intervention strategies to enhance male reproductive health.