子宫内膜类组装体的研究进展

Advances in endometrial assembloids

子宫内膜类器官是子宫内膜细胞自组织形成的三维聚集物,再现部分子宫内膜的结构与功能.子宫内膜类组装体在此基础上整合了其他细胞类型,如基质成纤维细胞、内皮细胞和免疫细胞等,更好地模拟了子宫内膜的细胞组成与功能.类器官和类组装体克服了体内子宫内膜的复杂性与伦理的限制,成为新的理想研究模型.本文综述了子宫内膜类组装体的培养方法、在植入等方面的应用,讨论了子宫内膜类组装体的研究进展与应用前景.

Endometrial organoids are three-dimensional aggregates formed by endometrial cells,which reproduce the structure and function of part of the endometrial.On this basis,endometrial assembloids integrate other cell types,such as stromal fibroblasts,endothelial cells,and immune cells,to better simulate the cell composition and function of the endometrial.Organoids and assembloids have overcome the complexity and ethical limitations of endometrium in vivo and become a new ideal research model.In this study,we reviewed the culture methods and applications of endometrial assembloids in embryo implantation,where its research progress and application prospects are discussed.