单纯疱疹病毒膜融合蛋白相互作用的研究进展

Research progress on herpes simplex virus membrane fusion protein interactions

单纯疱疹病毒(herpes simplex virus,HSV)是一种普遍存在的含双链DNA的包膜病毒。单纯疱疹病毒-1型(HSV-1)感染人体可引起口唇炎、结膜炎及脑炎等疾病,HSV-2感染可导致多年龄段的生殖器疱疹,这两种病毒均可在人体建立终身潜伏感染。HSV的多种膜蛋白相互作用触发膜融合是病毒进入宿主细胞的重要方式,本文通过分析糖蛋白的结构及其相互作用方式对由gD、gH、gL、gB 4种病毒糖蛋白组成的HSV保守的核心融合机制作一综述。由于目前全球尚无HSV疫苗获批上市,因此研究HSV与宿主细胞的作用方式对研发疫苗具有重要意义。

Herpes simplex virus(HSV)is a ubiquitous enveloped virus containing double-stranded DNA.HSV-1 infection can cause inflammation of the lips,conjunctivitis and encephalitis,HSV-2 infection can cause genital herpes at many ages,and both viruses can establish lifelong latent infection in the body.Membrane fusion triggered by the interaction of various HSV membrane proteins is an important way for viruses to enter host cells.This review introduced the conserved core fusion mechanism of HSV composed of four viral glycoproteins gD,gH,gL and gB by analyzing the structure of glycoproteins and their interaction modes.Since there is currently no HSV vaccine approved for marketing in the world,it is of great significance to study the mode of action of HSV and host cells for the development of vaccines.