参苓白术散联合双歧杆菌三联活菌肠溶胶囊治疗结肠腺瘤样息肉术后复发的疗效观察

Clinical Efficacy of Shenling Baizhu Powder Combined with Bifidobacterium Triple Viable Enteric-Coated Capsule in Treatment of Postoperative Recurrence of Colonic Adenomatous Polyps

目的:观察参苓白术散联合双歧杆菌三联活菌肠溶胶囊治疗结肠腺瘤样息肉术后复发的临床疗效。方法:选取2020年1月至2022年12月在我院接受诊治的86例结肠腺瘤样息肉术后患者,将其随机分为观察组和对照组,每组43例。对照组患者术后服用双歧杆菌三联活菌肠溶胶囊治疗,观察组在对照组治疗的基础上服用参苓白术散治疗,比较2组患者的疗效,中医症候积分比较以及术后6、12、18个月的复发情况。结果:治疗后观察组患者总有效率为93.02%,显著高于对照组的76.74%(P<0.05)。术前2组患者腹痛、大便次数、便血中医症候积分比较差异无统计学意义(P>0.05),术后6、12、18个月2组患者腹痛、大便次数、便血中医症候积分均低于术前,且观察组低于对照组(P<0.05)。术后6个月观察组复发2例,对照组复发8例;术后12个月观察组复发6例,对照复发14例;术后18个月观察组复发11例,对照复发21例;术后6、12、18个月观察组复发率均低于对照组(P<0.05)。结论:参苓白术散联合双歧杆菌三联活菌肠溶胶囊能显著改善结肠腺瘤样息肉术后患者临床症候,降低复发率,疗效显著。

Objective To observe the clinical efficacy of Shenling Baizhu Powder combined with bifidobacterium triple viable enteric-coated capsule in the treatment of postoperative recurrence of colonic adenomatous polyps.Methods A total of 86postoperative patients with colonic adenomatous polyps treated in our hospital from January 2020to December 2022were selected and randomly divided into the observation group and the control group,with 43cases in each group.The control group was treated with bifidobacterium triple viable enteric-coated capsule after operation,and the observation group was treated with Shenling Baizhu Powder on the basis of the control group.The efficacy,symptom scores of traditional Chinese medicine(TCM)and recurrence of the two groups were compared.Results After treatment,the total effective rate of the observation group was 93.02%,which was significantly higher than that of the control group(76.74%)(P<0.05).Before operation,there were no significant differences in TCM syndrome scores of abdominal pain,frequency of bowel movements and hematochezia between the two groups(P>0.05).Six,twelve and eighteen months after operation,TCM syndrome scores of abdominal pain,frequency of bowel movements and hematochezia in both groups were lower than those before opera-tion,which were lower in the observation group than in the control group(P<0.05).Six months after operation,there were 2recurrent cases in the observation group and 8recurrent cases in the control group.Twelve months after operation,there were 6recurrent cases in the observation group and 14recurrent ca-ses in the control group.Eighteen months after operation,there were 11recurrent cases in the observation group and 21recurrent cases in the control group.The recurrence rate of the observation group was lower than that of the control group 6,12and 18months after operation(P<0.05).Conclusion Shenling Baizhu Powder combined with bifidobacterium triple viable enteric-coated capsule can significantly improve the clinical symptoms and reduce the recurrence rate of postoperative colonic adenomatous polyps.