双歧杆菌四联活菌联合聚乙二醇散治疗便秘的疗效及对肠道菌群的影响

Clinical Efficacy of Bifidobacterium Quadruple Viable Bacteria Combined with Polyethylene Glycol Powder in Treatment of Constipation and Its Effect on Intestinal Flora

目的:探究双歧杆菌四联活菌联合聚乙二醇散治疗便秘的临床疗效及对肠道菌群的影响。方法:将76例便秘患者随机分为观察组和对照组,每组38例。对照组患者采用聚乙二醇散联合安慰剂治疗,观察组患者采用双歧杆菌四联活菌联合聚乙二醇散治疗,疗程为1个月。比较2组患者的临床疗效,治疗前后临床症状积分、肠道菌群水平以及不良反应发生情况。结果:观察组患者临床总有效率明显高于对照组(P<0.05);治疗前2组患者临床症状积分比较差异无统计学意义(P>0.05),治疗后2组患者临床症状评分均低于治疗前,且观察组低于对照组(P<0.05);治疗前2组患者肠道菌群水平比较差异无统计学意义(P>0.05),治疗后2组患者双歧杆菌、乳酸杆菌水平明显高于治疗前(P<0.05),大肠杆菌水平低于治疗前(P<0.05),且观察组患者双歧杆菌、乳酸杆菌水平高于对照组(P<0.05),大肠杆菌水平低于对照组(P<0.05);2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:双歧杆菌四联活菌与聚乙二醇散联用治疗便秘疗效显著,不但可以有效改善患者便秘症状,而且还能调节患者肠道菌群,具有较高的安全性和有效性,值得临床推广应用。

Objective To explore the clinical efficacy of bifidobacterium quadruple viable bacteria com-bined with polyethylene glycol powder in the treatment of constipation and its effect on intestinal flora.Methods Total 76patients with constipation were randomly divided into the observation group and the control group,38cases in each group.The control group was treated with polyethylene glycol powder combined with placebo,while the observation group was treated with bifidobacterium quadruple viable bacteria combined with polyethylene glycol powder,and the course of treatment was 1month.The clinical efficacy,clinical symptom scores,intestinal flora levels and occurrence of adverse reactions before and after treat-ment were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in clinical symptom scores between the two groups before treatment(P>0.05).The clinical symptom scores of both groups after treatment were lower than those before treatment,which were lower in the ob-servation group than in the control group(P<0.05).There was no statistical significance in the intestinal flora levels between the two groups before treatment(P>0.05).After treatment,the levels of bifidobac-terium and lactobacillus in both groups were significantly higher than those before treatment(P<0.05),which were higher in the observation group than in the control group(P<0.05).The levels of Escherich-ia coli were lower after treatment,which were lower in the observation group than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Bifidobacterium quadruple viable bacteria combined with polyethylene glycol powder is effective in the treatment of constipation,which can not only effectively improve the symptoms of constipation,but also regulate the intestinal flora of patients.It has high safety and effectiveness,and is worthy of clinical application.