代谢组学在体外循环心脏手术器官损伤中的研究进展

Research progress of metabolomics in organ damage during cardiac surgery with cardiopulmonary bypass

体外循环(CPB)主要应用于心脏手术,CPB会造成脑、心、肾等重要脏器的损害,产生相关的并发症。代谢组学是研究生物体受外部刺激所产生的全部变化的代谢产物的科学,CPB后机体的代谢物成分会发生变化。研究心脏手术围术期的代谢变化,可以为疾病的发病机制提供重要的见解,并有潜力识别新的生物标志物。本综述主要介绍代谢组学的现状,以及其在CPB心脏手术对脑、心、肾、肺等重要脏器损伤中的研究进展,并就代谢组学在该领域的未来做一展望。

Cardiopulmonary bypass(CPB)is mainly used in cardiac surgery.CPB can cause damage to the brain,heart,kidney and other important organs,and develop associated complications.Metabonomics is the science of studying the metabolites of all the changes in a biological system resulting from external stimuli,and the metabolite composition of the body will change after CPB.Studying metabolic changes in the perioperative period of cardiac surgery can provide important insights into the pathogenesis of the disease and potentially identify new biomarkers.This review mainly introduces the current status of metabolomics as well as its research progress in the brain damage,heart,kidney,lung and other important organs in CPB cardiac surgery,and looks into the future of metabolomics in this field.