糖尿病周围神经病变中西医发病机制及治疗的研究进展

Research Progress on Pathogenesis and Treatment of Diabetes Peripheral Neuropathy with Traditional Chinese and Western Medicine

糖尿病周围神经病变(DPN)属于糖尿病常见慢性并发症之一,近年来,其发病率和致残率逐年上升。中医认为DPN的根本病机在于脏腑阴阳气血亏虚,瘀血阻络,西医则认为糖脂代谢紊乱、神经营养因子(NTF)缺乏、氧化应激(OS)、自身免疫性疾病都能导致DPN。中医应用方药治疗、针刺治疗及中医物理治疗等多种手段,从多方面、多角度改善DPN患者的临床症状。西医则主要从纠正代谢紊乱、对症镇痛、抗氧化应激、营养神经及外科手术等方面予以治疗。文章通过大量阅读相关文献和结合临床实践观察从传统中医和现代西医两个角度对DPN发病机制及治疗方法进行归纳总结,为该病治疗提供新思路。

Diabetic peripheral neuropathy(DPN)is one of the common chronic complications of diabetes.In recent years,its incidence and disability rate are increasing year by year.Traditional Chinese medicine believes that the fundamental pathogenesis of DPN lies in deficiency of Qi and blood,Yin and Yang of Fu Zang,blood stasis and obstructing the meridians,while western medicine believes that the disorder of glucose and lipid metabolism,lack of neurotrophic factors(NTF),oxidative stress(OS)and autoimmune diseases can all lead to DPN.Traditional Chinese medicine applies various methods such as prescription therapy,acupuncture,and physical therapy to improve the clinical symptoms of DPN patients from multiple aspects and perspectives.Western medicine is mainly from the correction of metabolic disorders,symptomatic analgesia,anti-oxidative stress,nutritional nerve and surgical treatment.This paper summarizes the pathogenesis and treatment of DPN from the perspectives of traditional Chinese medicine and modern western medicine by reading a lot of relevant literature and combining clinical practice observation,providing new ideas for the treatment of DPN.