胱抑素C联合D-二聚体检测对早期糖尿病肾病的诊断价值

The value of cystatin C and D-dimer in the diagnosis of early diabetic nephropathy

目的:研究胱抑素C(Cys-C)联合D-二聚体(D-D)检测对早期糖尿病肾病的诊断价值。方法:选取2022年1—12月临沂市中医医院收治的134例2型糖尿病患者作为试验组,并将其分为早期糖尿病肾病组(DN组)和单纯糖尿病组(DM组),另选择67名健康人作为对照组,比较三组Cys-C、D-D水平。绘制受试者工作特征(ROC)曲线,探究两个指标单一检测和联合检测对早期糖尿病肾病的诊断效能。结果:试验组Cys-C、D-D水平均高于对照组,DN组Cys-C、D-D水平均高于DM组,差异均有统计学意义(P<0.05)。ROC曲线显示,Cys-C、D-D联合检测的曲线下面积(AUC)大于二者单独检测。结论:血清Cys-C、D-D水平联合诊断早期糖尿病肾病具有一定的价值,值得临床参考。

Objective To study the diagnostic value of cystatin C(Cys-C)combined with D-dimer(D-D)in early diabetes nephropathy.Methods 134 patients with type 2 diabetes admitted to Linyi Traditional Chinese Medicine Hospital from January to December 2022 were selected as the test group,and they were divided into early diabetes nephropathy group(DN group)and simple diabetes group(DM group).Another 67 healthy people were selected as the control group,and the levels of Cys-C and D-D in the test group and the control group were compared.Draw the receiver operating characteristic(ROC)curve,and explore the diagnostic efficacy of single detection and joint detection of two indicators for early diabetes nephropathy.Results The average levels of Cys-C and D-D level in the experimental group were higher than those in the control group,while the average levels of Cys-C and D-D level in the DN group were higher than those in the DM group,and the differences were statistically significant(P<0.05).The ROC curve shows that the area under the curve AUC for Cys-C and D-D combined detection is higher than that for both individual detection.Conclusions The symptoms of early diabetes nephropathy patients are relatively hidden,which makes clinical diagnosis and treatment difficult.Cys-C combined with D-D test can significantly improve the diagnostic efficiency,which is worthy of clinical attention.