益生菌在儿童呼吸系统疾病应用进展

Progress in the application of probiotics in respiratory diseases in children

肠道微生态承载着人类后天获得基因,参与人类正常生理和疾病病理过程,与人体健康密不可分。益生菌有拮抗病原微生物、增强上皮屏障或营养代谢以及刺激和促进机体免疫成熟等功能,目前已广泛用于儿童腹泻病、功能性胃肠道疾病及代谢性疾病等多种疾病。近年来益生菌也被用于呼吸系统疾病的辅助治疗,主要作用机制是通过黏膜免疫系统调节肺部免疫来实现。文章就益生菌防治呼吸系统疾病的机制及在儿童呼吸系统疾病中的临床进展作简要介绍。

The gut microbiota carries acquired genes,participates in normal physiological and pathological processes,and is closely related to human health.Probiotics have functions such as antagonizing pathogenic microorganisms,enhancing epithelial barriers or nutrient metabolism,and stimulating and promoting immune maturation in the body.They are currently widely used in various diseases such as childhood diarrhea,functional gastrointestinal diseases,and metabolic diseases.In recent years,probiotics have also been used as adjunctive therapies for respiratory diseases,with the main mechanism of action being achieved by regulating lung immunity through the mucosal immune system.The article briefly introduces the mechanism of probiotics in the prevention and treatment of respiratory diseases and their clinical progress in children's respiratory diseases.