从碳中心到硅中心:手性螺环双膦配体研究的发展

From the Carbon Center to the Silicon Center:Advances of Chiral Spiro Diphosphine Ligands

手性螺环配体和催化剂已被公认是一类优势手性配体和催化剂。手性螺环配体的相关研究,促进了不对称催化领域的发展。根据螺环中螺原子的不同,将螺环分为碳中心和硅中心的螺环骨架,分别讨论基于碳中心的具有螺[4.4]壬烷骨架、螺二氢茚骨架、螺壬二烯骨架、螺二色烷骨架以及基于硅中心的手性螺环双膦配体的合成及在不对称催化反应中的应用,为今后发展新的不对称催化体系提供了重要参考。

Chiral spiro ligands and catalysts have been recognized as a class of dominant chiral ligands and catalysts.The research on chiral spiro ligands has promoted the development of asymmetric catalysis.According to the dfference of spiro atoms in the spiro,the spiro is divided into carbon center spiro skeleton and silicon center spiro skeleton.The synthesis and application of chiral spiro diphosphine ligands based on carbon center with spiro[4.4]nonane skeleton,spirobindane skeleton,spirononadiene skeleton,spirobichroman skeleton and silicon center are discussed respectively.It provides an important reference for developing new asymmetric catalytic systems in the future.