基质金属蛋白酶-7在新生儿胆道闭锁诊断和预后评价中的研究进展

Research advances of matrix metalloproteinase-7 in the diagnosis and prognosis of neonatal biliary atresia

胆道闭锁(biliary atresia,BA)是以肝内、外胆管进行性炎症和纤维化为特征的严重肝胆疾病,早期诊断难度大,易延误患儿Kasai手术时机,部分患儿术后仍需接受肝移植,进展严重的患儿甚至死亡。基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)是基质金属蛋白酶家族之一,能够降解细胞外基质和其他基质,与BA联系紧密。本文主要介绍目前MMP-7在BA诊断和预后评价中的研究进展,并对相关研究结果予以概述和探讨。

As a rare disease of infancy,biliary atresia(BA)is characterized by progressive inflammation and fibrination of intra/extra-hepatic bile ducts.The difficulty of early diagnosis of this disease results in an advanced age at Kasai surgery and a significantly higher rate of postoperative mortality and liver transplantation.Matrix metalloproteinase-7(MMP-7)is a matrix metalloproteinase capable of degrading extracellular matrix and other matrices.It is correlated closely with BA.In basic experiments,serum level of MMP-7 in BA children was significantly higher than that of non-BA subjects.This review focused upon the latest researches of MMP-7 in the diagnosis and prognosis of BA.