活血化瘀中医干预法对肝硬化营养不良患者的应用效果及血清营养指标影响

The Application Effect of Traditional Chinese Medicine Intervention on Promoting Blood Circulation and Resolving Stasis in Patients with Liver Cirrhosis and Malnutrition and the Influence of Serum Nutritional Indicators

目的探讨活血化瘀中医干预法对肝硬化营养不良患者的应用效果及血清营养指标影响。方法选取2022年6月—2023年3月甘肃省第二人民医院收治的82例肝硬化营养不良患者作为研究对象,应用随机数表法将其分为观察组与对照组,每组41例。对照组患者采取常规肝硬化治疗和营养干预,观察组在对照组基础上增加活血化瘀中医干预法,对比两组患者治疗前后肝功能指标、营养指标表达水平以及并发症发生情况。结果治疗前,两组患者碱性磷酸酶(ALP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者ALP、ALT和AST水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者转铁蛋白(TRF)、前白蛋白(PAB)、血清白蛋白(Alb)和血红蛋白(Hb)等相关营养指标水平比较,差异无统计学意义(P>0.05);治疗后,两组TRF、PAB、Alb、Hb水平均升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组患者肝性脑病、肝肾综合征、消化道出血、感染等并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论对肝硬化营养不良患者采取活血化瘀中医干预法治疗能够进一步改善患者肝功能,提升患者血清营养指标水平,降低并发症发生率,值得临床应用。

Objective To explore the application effect of traditional Chinese medicine intervention method for promoting blood circulation and resolving blood stasis on patients with liver cirrhosis and malnutrition,as well as the impact of serum nutritional indicators.Methods A total of 82 patients with cirrhosis and malnutrition who were admitted to the Second People's Hospital of Gansu Province from June 2022 to March 2023 were selected as the study objects.They were divided into observation group and control group by random number table method,with 41 cases in each group.The control group received conventional treatment of cirrhosis and nutrition intervention,and the observation group was additionally given the traditional Chinese medicine intervention method to promote blood circulation and remove blood stasis.The liver function indexes,nutritional index expression levels and complications of the two groups before and after treatment were compared.Results There was no signifi cant diff erence in the levels of Alkaline phosphatase(ALP),Glutamic pyruvic transaminase(ALT),Glutamic transaminase(AST)between the two groups of patients before treatment(P>0.05).After treatment,the levels of ALP,ALT,and AST in both groups of patients decreased,and the observation group was lower than the control group(P<0.05).There was no signifi cant diff erence in the nutritional indicators related to Transferrin(TRF),Prealbumin(PAB),serum albumin(Alb)and hemoglobin(Hb)between the two groups of patients before treatment(P>0.05).After treatment,the levels of TRF,PAB,Alb,and Hb in the treatment two groups increased,and the observation group was higher than the control group(P<0.05).The incidence of complications such as hepatic encephalopathy,hepatorenal syndrome,gastrointestinal bleeding,and infection in the observation group was signifi cantly lower than that in the control group(P<0.05).Conclusion The traditional Chinese medicine intervention method of promoting blood circulation and resolving blood stasis can further improve liver function,enhance serum nutritional index levels,and reduce the incidence of complications in patients with liver cirrhosis and malnutrition.It is worthy of clinical application.