抗心磷脂抗体水平在稽留流产中的作用及与EMAb相关性分析

The Role of Anticardiolipin Antibody Levels in Missed Miscarriage and Its Correlation with EMAb

目的探究抗心磷脂抗体水平在稽留流产中的作用,并分析其与抗子宫内膜抗体(the endometrial antibodies,EMAb)水平的相关性。方法选择2019年10月—2022年8月于滕州市妇幼保健院接受治疗的200例稽留流产患者作为研究组,另取同期于滕州市妇幼保健院接受体格检查的200名正常妊娠女性为对照组,比较两组血清抗心磷脂抗体水平及EMAb水平差异,采用Pearson相关性分析探究抗心磷脂抗体水平与EMAb水平相关性,通过绘制ROC曲线的方式分别计算抗心磷脂抗体水平与EMAb在稽留流产中的诊断效能。结果研究组患者抗心磷脂抗体IgG、抗心磷脂抗体IgA、抗心磷脂抗体IgM水平、EMAb水平均明显高于对照组,差异有统计学意义(P<0.05);研究组患者血清EMAb水平与抗心磷脂抗体IgG、抗体IgA、抗体IgM水平均呈现正相关关系(r=0.552、r=0.586、r=0.417,P<0.05);血清抗心磷脂抗体IgG、抗心磷脂抗体IgA、抗心磷脂抗体IgM、EMAb对稽留流产的诊断曲线下面积(AUC)分别为0.930(95%CI:0.886~0.974,P<0.05)、0.972(95%CI:0.940~1.000,P<0.05)、0.990(95%CI:0.979~1.000,P<0.05)、0.959(95%CI:0.927~0.990,P<0.05)。结论稽留流产女性抗心磷脂抗体水平与EMAb水平均明显呈现升高状态,且患者抗心磷脂抗体水平与EMAb水平呈现明显正相关性,抗心磷脂抗体水平与EMAb水平对稽留流产有一定的参考价值。

Objective The role of anticardiolipin antibody level in residual abortion was explored,and its correlation with the level of anti-endometrial antibody(the endometrial antibodies,EMAb)was analyzed.Methods A total of 200 patients with missed abortion who received treatment in our hospital from October 2019 to August 2022 were selected as the study group,and 200 normal pregnant women who received physical examination in our hospital at the same time were selected as the control group.By comparing the differences in serum antiardiolipin antibody level and EMAb level between the two groups,the correlation between the antianticardiolipin antibody level and EMAb level was explored,and the diagnostic efficacy of the anticardiolipin antibody level and EMAb was calculated by drawing ROC(Receiver operating characteris)curve.Results The levels of anticardiolipin antibody IgG,anticardiolipin antibody IgA,anticardiolipin antibody IgM,and EMAb in the study group were significantly higher than those in the control group(P<0.05).The serum EMAb levels of patients in the study group were positively correlated with their levels of anticardiolipin IgG antibodies,IgA antibodies,and IgM antibodies(r=0.552,r=0.586,r=0.417,P<0.05).The area under curve(AUC)of serum anticardiolipin IgG antibodies,anticardiolipin IgA antibodies,anticardiolipin IgM antibodies,and EMAb for missed abortion were 0.930(95%CI:0.886~0.974,P<0.05),0.972(95%CI:0.940~1.000,P<0.05),0.990(95%CI:0.979~1.000,P<0.05),and 0.959(95%CI:0.927~0.990,P<0.05).Conclusion The level of anti-cardiolipin antibody and EMAb level in women with retained abortion were significantly increased,and the level of anti-cardiolipin antibody showed a positive correlation with EMAb,and the level of anti-cardiolipin antibody and EMAb had certain reference value for retained abortion.