大理地区慢性光化性皮炎患者最小红斑量和光斑贴试验分析

Analysis of Minimal Erythema Dose and Photopatch Test in Patients with Chronic Actinic Dermatitis in Dali Region

目的:检测大理地区慢性光化性皮炎(CAD)患者最小红斑量(MED)及光斑贴试验,探讨CAD患者致病光谱差异及可能的致敏物质。方法:采用日光模拟器对25例CAD患者和20例健康志愿者进行MED检测,应用瑞敏标准光斑贴试剂盒进行光斑贴试验。结果:CAD患者的长波紫外线最小红斑量(UVA-MED)为25.63 J/cm^(2),中波紫外线最小红斑量(UVB-MED)为20.56mJ/cm^(2),健康志愿者UVA-MED为49.92 J/cm^(2),UVB-MED为38.80 mJ/cm^(2),CAD患者和健康志愿者相比MED值均显著降低(P<0.05);CAD患者光斑贴试验阳性率为44%,常见的光变应原为:2-(4-二乙氨基-2-羟基苯甲酰基)-苯甲酸己酯、盐酸异丙嗪和2-羟基-4-甲氧基苯酮。结论:CAD患者对UVA、UVB均敏感,光接触变应原的暴露可能是CAD的诱发因素。

Objective:To investigate the minimal erythema dose(MED)and photopatch test in patients with chronic actinic dermatitis(CAD)in Dali region,aiming to explore the differences in the pathogenic spectrum of CAD patients and potential sensitizing substances.Methods:MED was measured using a solar simulator in 25 CAD patients and 20 healthy volunteers.The photopatch test was conducted using the RIMIN standard photopatch test reagent kit.Results:The long-wave ultraviolet minimal erythema dose(UVAMED)for CAD patients was 25.63 J/cm^(2),and the medium-wave ultraviolet minimal erythema dose(UVB-MED)was 20.56 mJ/cm^(2).The UVA-MED for healthy volunteers was 49.92 J/cm^(2),and the UVB-MED was 38.80 mJ/cm^(2).The MED values in CAD patients were significantly lower compared to healthy volunteers(P<0.05).The positive rate of photopatch test in CAD patients was 44%,with common photoallergens including hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate,promethazine hydrochloride,and 2-hydroxy-4-methoxybenzophenone.Conclusion:CAD patients are sensitive to both UVA and UVB,and exposure to photocontact allergens may be an inducing factor for CAD.