T1期乳腺癌超声特征与ER、PR、HER-2、Ki-67表达的相关性分析

Correlation Analysis of Ultrasound Features in T1-Stage Breast Cancer with the Expression of ER,PR,HER-2,and Ki-67

目的:探讨T1期乳腺癌超声声像图特征与雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER-2)、细胞增殖相关抗原Ki-67表达的相关性。方法:回顾性收集2012年1月至2021年6月经病理证实为单发乳腺恶性肿瘤患者493例的病历资料,记录超声特征及免疫组化结果,并对二者进行相关性分析。结果:ER、PR、HER-2、Ki-67阳性率分别为78.09%、67.34%、21.10%、71.60%;ER与PR表达呈正相关,HER-2与ER、PR表达呈负相关;Ki-67与HER-2表达呈正相关,与ER、PR表达呈负相关。ER阳性表达与形态不规则、边缘不规整、间质脂肪侵犯、有高回声晕等超声特征有关,PR阳性表达与病灶内部成分、腋窝淋巴结转移等超声特征有关,Ki-67阳性表达与边界不清晰、间质脂肪侵犯、有高回声晕等超声特征有关,差异均有统计学意义(P<0.05)。结论:T1期乳腺癌的超声征象与ER、PR、Ki-67表达存在一定的相关性,超声声像图的变化可以提示肿瘤生物学行为,为医生临床决策提供参考。

Objective:To explore the correlation between ultrasound imaging features of T1-stage breast cancer and the expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER-2),and Ki-67.Methods:A retrospective collection of medical records of 493 patients confirmed with solitary malignant breast tumors from January 2012 to June 2021 was conducted.Ultrasound features and immunohistochemical results were recorded,and their correlation was analyzed.Results:The positive rates of ER,PR,HER-2,and Ki-67 were 78.09%,67.34%,21.10%,and 71.60%,respectively.ER expression was positively correlated with PR expression,while HER-2 expression was negatively correlated with ER and PR expression.Ki-67 expression was positively correlated with HER-2 expression and negatively correlated with ER and PR expression.ER-positive expression was associated with irregular morphology,irregular margins,interstitial fat invasion,and high echo halos in ultrasound features.PR-positive expression was associated with internal lesion components and axillary lymph node metastasis in ultrasound features.Ki-67-positive expression was associated with unclear boundaries,interstitial fat invasion,and high echo halos in ultrasound features,with statistical significance(P<0.05).Conclusion:Ultrasound features of T1-stage breast cancer are correlated with the expression of ER,PR,and Ki-67.Changes in ultrasound images can provide indications of tumor biological behavior,offering valuable references for clinical decision-making.