T1 mapping技术用于评估心尖肥厚型心肌病患者心肌钆沉积

T1 mapping technique for evaluating myocardial gadolinium deposition in patients with apical hypertrophic cardiomyopathy

目的观察T1 mapping技术用于评估心尖肥厚型心肌病(AHCM)患者心肌钆沉积的可行性。方法回顾性分析60例AHCM患者资料,根据是否接受含钆对比剂(GBCA)注射分为增强组和对照组各30例;基于2组心脏T1 mapping测量左心室基底部、中间部、心尖部心肌T1值及相应层面脾脏T1值,计算T1相对值(T1R),比较组间及增强组内左心室不同部位心肌T1R,并对增强组T1R基于性别、年龄、体质量指数、心功能、高血压、高血脂、糖尿病、心尖厚度、射血分数、延迟强化、首次增强检查至末次复查间隔时间及GBCA总量进行进一步分析。结果组间T1R_(基底部)、T1R_(中间部)、T1R_(心尖部)差异均无统计学意义(t=0.329、1.484、0.720,P均>0.05)。增强组内,左心室不同部位心肌T1R差异无统计学意义(F=0.765,P>0.05),不同性别及有无高血压患者间心肌T1R差异均有统计学意义(P均<0.05)。结论T1 mapping技术可用于评估AHCM患者心肌钆沉积。

Objective To observe the feasibility of T1 mapping technique for evaluating myocardial gadolinium deposition in patients with apical hypertrophic cardiomyopathy(AHCM).Methods Data of 60 AHCM patients were retrospectively analyzed.The patients were divided into enhanced group and control group according to underwent gadolinium-based contrast agent(GBCA)enhanced examination or not(each n=30).Myocardial T1 value at the basal,middle and apical myocardium of the left ventricle as well as spleen T1 at the same layers were measured.T1 relative-value(T1R)was calculated and then compared between groups and among different parts of left ventricle in enhanced group.T1R in enhanced group were further analyzed based on gender,age,body mass index,cardiac function,hypertension,hyperlipidemia,diabetes,apical thickness,ejection fraction,delayed enhancement and interval time from the first enhanced examination to the last review and total dose of GBCA.Results No significant difference of T1R_(basal),T1R_(middle) nor T1R _(apical) was found between groups(t=0.329,1.484,0.720,all P>0.05),nor of T1R in different parts of left ventricle within enhanced group(F=0.765,P>0.05).In enhanced group,significant differences of myocardial T1R was found between different genders as well as patients with or without hypertension(both P<0.05).Conclusion T1 mapping technology could be used for evaluating myocardial gadolinium deposition in patients with AHCM.