pH响应纤维素凝胶抗菌膜的制备与性能研究

Preparation and properties of pH responsive cellulosegel antibacterial membrane

以羧甲基纤维素钠和聚乙二醇为原料,通过交联、凝胶化形成多孔网络结构,制备具有pH响应性能的凝胶膜。将其浸泡在单宁酸溶液中赋予样品抗菌性能,并对抗菌膜的微观结构、溶胀性能、体外药物释放、抗氧化性能、抗菌性能等进行了表征。结果表明:制备好的抗菌膜具有良好的多孔结构,羧甲基纤维素钠上的羧基赋予抗菌膜一定的pH响应性能,使其在不同pH值下表现出差异性的溶胀性和体外释药性,载药后样品的抗氧化性提升至91.33%,对大肠杆菌和金黄色葡萄球菌的抑菌率均达到90%以上。该抗菌膜在药物缓释型敷料等方面具有很大的应用前景。

Using carboxymethyl cellulose sodium and polyethylene glycol as raw materials,a porous network structure was formed through cross-linking and gel,and a pH responsive gel membrane was prepared.The sample obtained antibacterial properties by soaked in tannic acid solution,and the microstructure,swelling properties,in vitro drug release,antioxidant properties,and antibacterial properties of the antibacterial membrane were characterized.The results show that the prepared antibacterial membrane has a good porous structure.The carboxyl group on carboxymethyl cellulose sodium endows the antibacterial membrane with certain pH responsiveness,which makes it exhibit anisotropic swelling and drug release in vitro at different pH values.After drug loading,the antioxidant capacity of the sample increases to 91.33%,and the antibacterial rate against Escherichia coli and Staphylococcus aureus reaches more than 90%.This antibacterial film has great application prospects in drug sustained-release dressings and other fields.