漆黄素对力竭运动大鼠骨骼肌细胞凋亡和线粒体功能的影响

Effects of Fisetin on Apoptosis and Mitochondrial Function of Skeletal Muscle Cells in Exhausted Exercise Rats

漆黄素(fisetin,FIS)是一种来源于各种水果、蔬菜、坚果中的膳食类黄酮,是一种一致的膳食营养补充剂。本研究旨在探讨草莓源性漆黄素对力竭运动大鼠骨骼肌细胞凋亡和线粒体功能的影响。力竭运动通常伴随着炎症反应和氧化应激,导致骨骼肌损伤和线粒体功能障碍。漆黄素被广泛研究并被认为具有抗氧化和抗炎作用。本研究使用力竭运动大鼠模型,研究了漆黄素的保护作用。结果显示,漆黄素处理显著减轻了力竭运动引发的外周炎症,并抑制了骨骼肌细胞凋亡。此外,漆黄素剂量依赖性地提高了骨骼肌线粒体酶活性,改善了线粒体呼吸功能,并促进了线粒体生物发生。这些发现表明,草莓源性漆黄素可能作为一种潜在的运动补充剂,有助于维护骨骼肌健康和线粒体功能。

Fisetin(FIS)is a dietary flavonoid derived from various fruits,vegetables,and nuts.It is a consistent dietary nutritional supplement.This study aimed to investigate the impact of strawberry-derived fisetin on apoptosis and mitochondrial function in the skeletal muscle cells of exhaustive exercise-induced rats.Exhaustive exercise is typically accompanied by inflammatory responses and oxidative stress,leading to skeletal muscle damage and mitochondrial dysfunction.Fisetin has been extensively studied and is considered to have antioxidant and anti-inflammatory properties.This study utilized an exhaustive exercise-induced rat model to examine the protective effects of fisetin.The results showed that fisetin treatment significantly reduced the peripheral inflammation induced by exhaustive exercise and inhibited skeletal muscle cell apoptosis.Furthermore,fisetin dose-dependently increased skeletal muscle mitochondrial enzyme activity,improved mitochondrial respiratory function,and promoted mitochondrial biogenesis.These findings suggest that strawberry-derived fisetin may serve as a potential dietary supplement for exercise,contributing to the maintenance of skeletal muscle health and mitochondrial function.