人参活性物质人参皂苷Rb1对力竭性离心运动大鼠心肌线粒体功能的影响

Effects of Active Component Ginsenoside Rb1 on Myocardial Mitochondrial Function in Exhaustive Exercise-induced Rats

为探究人参活性物质人参皂苷Rb1对力竭性离心运动大鼠心肌线粒体功能的影响。本研究选用SPF级雄性SD大鼠,将其分成不同的实验组,分别给予人参皂苷Rb1处理和进行力竭性离心运动。通过采集心肌组织样本,运用生物标志物、RT-qPCR等分析方法,对心肌细胞凋亡、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)、ATP含量以及线粒体呼吸链复合物活性等方面进行了评估。研究结果表明,人参皂苷Rb1的处理在力竭性离心运动大鼠中显著改善了心肌细胞凋亡水平,提高了SOD和CAT的活性,减少了MDA的水平,增加了ATP的含量,并促进了线粒体呼吸链复合物的活性。这些发现揭示了人参皂苷Rb1对心肌线粒体功能的保护作用,为进一步研究和开发心脏健康领域的治疗策略提供了有益信息。

To investigate the effects of ginsenoside Rb1,an active component of ginseng,on myocardial mitochondrial function in exhaustive exercise-induced rats.SPF-grade male SD rats were divided into different experimental groups,subjected to ginsenoside Rb1 treatment,and underwent exhaustive exercise.Myocardial tissue samples were collected,and various analytical methods,including assessments of myocardial cell apoptosis,superoxide dismutase(SOD),catalase(CAT),malondialdehyde(MDA)levels,ATP content,and mitochondrial respiratory chain complex activity,were employed.The results of the study indicated that ginsenoside Rb1 treatment significantly reduced myocardial cell apoptosis,enhanced SOD and CAT activities,decreased MDA levels,increased ATP content,and promoted the activity of mitochondrial respiratory chain complexes in exhaustive exercise-induced rats.These findings highlight the protective role of ginsenoside Rb1 on myocardial mitochondrial function,providing valuable insights for further research and development of therapeutic strategies in the field of cardiac health.