基于数据挖掘某院中医药治疗腹泻型肠易激综合征的用药规律

Exploration on medication rules of Chinese medicine in treatment of spleen deficiency diarrheal irritable bowel syndrome based on data mining

目的 采用数据挖掘方法探讨医院中医药治疗脾虚腹泻型肠易激综合征(IBS-D)的组方用药规律。方法 检索2016—2022年贵州某医院中医药治疗脾虚型IBS-D处方,采用Microsoft Excel 2007建立中药处方信息表,利用SPSS 23.0与SPSS Modeler18.0软件进行性味归经、功效、频数、关联规则、聚类分析等以挖掘医院中医药治疗脾虚型IBS-D的用药规律。结果 共纳入中药处方502首,处方中药味多见甘味,药性以温、平性为主,多归于脾、胃经,治疗药物以补虚药、行气药为主,药物使用频次较高的中药有白术、木香、陈皮等;治疗常用药对组合有白术-木香、白术-陈皮、木香-陈皮等,聚类分析得出3类处方,主要功效益气健脾、行气化痰、渗湿止泻等。结论 医院中医药治疗脾虚型IBS-D组方规律以益气健脾、行气化痰、渗湿止泻为主要治法,临床常用香砂六君子汤、参苓白术散等加减方辨证治疗。

Objective To explore the rule of prescription medication in the treatment of spleen deficiency diarrheal irritable bowel syndrome(IBS-D)with traditional Chinese medicine by using data mining method.Methods The prescriptions of the Second Affiliated Hospital of Guizhou University of Chinese Medicine for the treatment of spleen deficiency IBS-D were searched from 2016 to 2022.Microsoft Excel 2007 was used to establish the TCM prescription information table and SPSS 23.0 and SPSS Modeler18.0 software were used to conduct nature and taste normalization,efficiency,frequency,association rules,cluster analysis etc in order to find out the medication rules of the hospital's TCM treatment of spleen deficiency diarrheal IBS-D.Results A total of 502 TCM prescriptions were included and the medicinal taste was mostly sweet and the medicinal property was mainly moderate,mostly attributed to the spleen and stomach channel.The main therapeutic drugs were deficiency tonifying drugs and energy promoting drugs.The most frequently used Chinese medicines included white rhizoma,wood fragrance,orange peel and so on.The combinations of common drugs used in treatment included white artificial-wood fragrance,white artificial-orange peel,wood artificial-orange peel etc.Three kinds of prescriptions were obtained by cluster analysis,the main benefits were energy strengthening spleen,energy removing phlegm,dampness preventing diarrhea and so on.Conclusion The IBS-D prescription of spleen deficiency in the hospital is mainly used to invigorate energy and spleen,reduce energy and phlegm,and reduce dampness and diarrhea.Fragrant sand Liujunzi decoction,Shenling Baizhu powder are commonly used in clinical practice.