激活蛋白-1复合体与缺血性卒中

Activator protein-1 complex and ischemic stroke

激活蛋白-1(activator protein-1, AP-1)复合体是由Jun、Fos、转录激活因子及MAF蛋白亚基组成的转录因子复合体, 参与细胞增殖、分化、凋亡以及应激反应等生理和病理学过程。近年来研究表明, AP-1复合体在缺血性卒中中发挥着重要作用, 参与缺血性脑损伤后小胶质细胞激活、神经元凋亡等过程, 影响神经炎症的进展和卒中后神经功能缺损程度。

The activator protein-1(AP-1)complex is a transcription factor complex composed of Jun,Fos,activating transcription factors,and MAF protein subunits,involved in physiological and pathological processes such as cell proliferation,differentiation,apoptosis,and stress response.In recent years,research has shown that the AP-1 complex plays an important role in ischemic stroke,participating in processes such as microglial activation and neuronal apoptosis after ischemic brain injury,affecting the progression of neuroinflammation and the degree of neurological dysfunction after stroke.