微反应器连续合成氨基乙酸工艺研究

Process Research on Continuous Synthesis of Aminoacetic Acid in Microreactor

目前国内氨基乙酸生产大多采用的生产工艺是釜式间歇法,但该工艺存在生产效率低、产品质量低、氨气易泄露和各工段人工使用较多等问题。而微反应器采用连续流动反应,能够精准控制反应的温度和时间,具有极高的换热效率,能够有效规避釜式反应的缺点。本研究选用LT型微通道反应器作为反应容器,以质量分数为81.50%的3.00 kg氯乙酸水溶液、质量分数为25.00%的1.15 kg乌洛托品水溶液和0.70 kg补水量为原料,通过控制变量实验方法测得在温度为70±2℃、压力为0.8 MPa、pH为6.0±0.2、氯乙酸流量为48 mL·min^(-1)的条件下进行反应可高效合成氨基乙酸,收率为90.20%。结果表明:利用微反应器连续化生产氨基乙酸能提高生产的自动化程度、提高反应效率,同时节省人力。

At present,most of the production processes of aminoacetic acid in China are kettle batch process,but this process has some problems,such as low production efficiency,low product quality,easy leakage of ammonia gas and more manual use in each section.The microreactor adopts continuous flow reaction,which can accurately control the temperature and time of the reaction,has extremely high heat exchange efficiency,and can effectively avoid the shortcomings of the kettle reaction.In this study,LT-type microchannel reactor was selected as the reaction vessel,and 3.00 kg of chloroacetic acid aqueous solution with mass fraction of 81.50%,1.15 kg of urotropine aqueous solution with mass fraction of 25.00%and 0.70 kg of water replenishment were used as raw materials.Through the control variable experimental method,it was measured that the reaction could be efficiently synthesized under the conditions of temperature of 70±2℃,pressure of 0.8 MPa,pH of 6.0±0.2,and chloroacetic acid flow rate of 48 mL·min^(-1),with a yield of 90.20%.The results show that the continuous production of aminoacetic acid by microreactor can improve the degree of automation of production,improve the reaction efficiency,and save manpower.