滋肾育胎丸结合地屈孕酮对早期不明原因复发性流产患者的效果分析

Analysis of the effect of Zishen Yutai Pill combined with dexamethasone on patients with early unexplained recurrent miscarriage

目的:探讨滋肾育胎丸+地屈孕酮对早期不明原因复发性流产患者在保胎治疗中的价值。方法:抽取2019年7月至2022年7月在本院就诊的86例早期不明原因复发性流产患者,根据治疗方案的差异将其分为对照组(n=43,地屈孕酮)、观察组(n=43,滋肾育胎丸结合地屈孕酮),对比治疗有效率、中医证候积分、血清因子水平、保胎结果以及安全性。结果:组间治疗有效率对比(P<0.05)。治疗后,观察组中医证候积分低,孕酮、人绒毛膜促性腺激素水平高(P<0.05)。观察组再次流产率为9.30%,低于对照组的32.56%(P<0.05);观察组早产胎儿无死亡发生,对照组早产胎儿死亡率为2.33%,组间对比(P>0.05);观察组足月胎儿33例、对照组足月胎儿17例,组间保胎成功率对比(P<0.05)。两组患者在药物使用后,均未出现显著不良反应,证实联合药物使用安全性较好。结论:针对早期不明原因复发性流产患者在保胎过程中使用滋肾育胎丸结合地屈孕酮,在提升患者保胎效果、改善内分泌方面效果尚佳,患者的保胎结局相对较好,且联合用药的安全性尚可。

Objective:To explore the application effect of Zishen Yutai Wan combined with dexamethasone progesterone in the treatment of early unexplained recurrent miscarriage.Method:86 patients with early unexplained recurrent miscarriage admitted to our hospital from July 2019 to July 2022 were selected and divided into a control group(n=43,dexamethasone progesterone)and an observation group(n=43,Zishen Yutai Wan combined with dexamethasone progesterone)based on the differences in treatment plans.The treatment efficacy,traditional Chinese medicine syndrome scores,serum factor levels,pregnancy protection results,and safety of the two groups of patients were compared.Result:Comparison of treatment effectiveness rates between groups(P<0.05).After treatment,the observation group had low TCM syndrome scores and high levels of progesterone and human chorionic gonadotropin(P<0.05).The rate of recurrent miscarriage in the observation group was 9.30%,lower than 32.56% in the control group(P<0.05);there were no deaths of premature fetuses in the observation group,while the mortality rate of premature fetuses in the control group was 2.33%,with a comparison between groups(P>0.05);There were 33 full-term fetuses in the observation group and 17 full-term fetuses in the control group,with a comparison of the success rates of fetal preservation between the two groups(P<0.05).Conclusion:For patients with early unexplained recurrent miscarriage,the use of Zishen Yutai Pill combined with dexmedroxyprogesterone during the pregnancy protection process has a good effect in enhancing the patient's pregnancy protection effect and improving endocrine function.The patient's pregnancy protection outcome is relatively good,and the safety of the combined medication is still acceptable.It is suitable for clinical promotion and use.