CMV联合HPV与Reid阴道镜评分指数对高级别宫颈鳞状上皮内病变进展为宫颈癌联合诊断预评估价值分析

Analysis of the pre evaluation value of CMV combined with HPV and Reid colposcopy scoring index in the diagnosis of advanced cervical squamous intraepithelial lesions progression to cervical cancer

目的:探讨巨细胞病毒(CMV)联合人乳头瘤病毒(HPV)与Reid阴道镜评分指数对预测高级别宫颈鳞状上皮内病变(HSIL)进展为宫颈癌的诊断价值。方法:回顾性分析2021年1月至2022年1月沂源县人民医院妇产科收治的83例HSIL者的临床资料,进行CMV测定、HPV测定、Reid阴道镜评分以及病理检测,以病理结果作为预测HSIL进展成宫颈癌的金标准,评价单一的测定项目与联合测定的应用价值。结果:进行1年随访,随访结果同病理预测的结果一致,主要是证实31例(37.35%)HSIL进展为宫颈癌,采取CMV联合HPV与Reid阴道镜评分指数对于预测HSIL进展宫颈癌,在同金标准方式一致率均是高于单项的判定方式,此外联合方式的敏感度、准确度及阴性预测值分别为96.77%、98.80%、98.11%,均是高于单项检测方式(P<0.05)。结论:应用CMV联合HPV与Reid阴道镜评分指数用于预测HSIL进展为宫颈癌的价值突出,对预防宫颈癌及早期干预有重要帮助。

Objective:To explore the diagnostic value of cytomegalovirus(CMV)combined with human papillomavirus(HPV)and Reid colposcopy score index in predicting the progression of high-grade cervical squamous intraepithelial lesions(HSIL)to cervical cancer.Method:A retrospective analysis was conducted on the clinical data of 83 HSIL patients admitted from January 2021 to January 2022.CMV,HPV,Reid colposcopy scores,and pathological tests were performed.The pathological results were used as the gold standard for predicting the progression of HSIL to cervical cancer,and the application value of a single test item and a combined test was evaluated.Result:A one-year follow-up was conducted,and the follow-up results were consistent with pathological predictions.The main reason was that 31 cases(37.35%)of HSIL advanced to cervical cancer.The CMV combined with HPV and Reid colposcopy scoring index were used to predict the progression of HSIL to cervical cancer.The consistency rate of the same gold standard method was higher than that of the single judgment method.In addition,the sensitivity,accuracy,and negative predictive values of the combined method were 96.77%,98.80%,and 98.11%,respectively,Both were higher than single detection methods(P<0.05).Conclusion:The application of CMV combined with HPV and Reid colposcopy scoring index in predicting the progression of HSIL to cervical cancer is of great value,and has important help in preventing cervical cancer and early intervention,which is worth promoting.