依达拉奉右莰醇结合阿替普酶溶栓对急性脑梗死患者脑血流动力学及颈动脉超声指标的影响

Effect of Edalavondexol Combined with Atteplase Thrombolysis on Cerebral Hemodynamics and Carotid Ultrasound Index in Patients with Acute Cerebral Infarction

目的分析依达拉奉右莰醇结合阿替普酶溶栓对急性脑梗死(ACI)患者脑血流动力学及颈动脉超声指标的影响。方法选取我院2019年6月-2022年10月收治的453例ACI患者为例,掷硬币法分为2组,对照组(n=220例)采取阿替普酶溶栓治疗,观察组(n=233例)另加用依达拉奉右莰醇治疗,对比两组治疗效果、脑血流动力学、颈动脉超声指标的变化。结果两组治疗有效率对比,差异显著(χ^(2)值=51.662,P<0.001)。与治疗前相比,治疗后两组双侧颅内动脉椎动脉(VA)、大脑中动脉(MAC)、大脑前动脉(ACA)水平有所下降,且治疗后,观察组与对照组左侧VA、右侧MAC、左侧ACA对比,差异显著(P<0.05)。观察组颈动脉内膜-中层厚度(IMT)、颈总动脉内径(CAD)、阻力指数(RI)水平均低于对照组,舒张末期血流速度(EDV)水平均高于对照组,差异显著(P<0.05)。观察组低切黏度(LSV)、高切黏度(HSV)、红细胞比容(HCT)、血浆黏度(PV)水平均低于对照组,差异显著(P<0.05)。结论联合用药方案可有效治疗疾病,也可改善ACI患者神经功能和血流动力学指标,可推广。

Objective To analyze the effect of edalavone dodenol and alteplase thrombolysis on cerebral hemodynamics and carotid ultrasound index in patients with acute cerebral infarction(ACI).Methods 453 cases of ACI patients admitted to our hospital from June 2019 to October 2022 were selected.The coin throwing method was divided into two groups.The control group(n=220 cases)was treated with alteplase thrombolysis,and the observation group(n=233 cases)was treated with edaravondexol to compare the treatment effect,cerebral hemodynamics and carotid ultrasound index between the two groups.Results Treatment response efficiency between the two groups varied significantly(χ^(2) value=51.662,P-value<0.001).Compared with before treatment,the levels of bilateral intracranial artery(VA),middle cerebral artery(MAC)and anterior cerebral artery(ACA)decreased after treatment,and the left VA,left MAC and left ACA between the observation group and the control group were significantly(P<0.05).The carotid artery intima-middle layer thickness(IMT),common carotid artery internal diameter(CAD),resistance index(RI)levels were lower than the control group,and the end-diastolic blood velocity(EDV)levels were higher than the control group,with significant differences(P<0.05).In the observation group,low shear viscosity(LSV),high shear viscosity(HSV),red blood cell volume(HCT),and plasma viscosity(PV)levels were all lower than those in the control group,with significant differences(P<0.05).Conclusion The combination regimen can effectively treat the disease,and can also improve the neurological function and hemodynamic indexes in ACI patients,which can be generalized.