羟考酮剂量优化对乳腺癌骨转移癌痛患者镇痛效果及安全性的影响

The Effect of Oxycodone Dose Optimization on the Analgesic Effect and Safety of Breast Cancer Patients with Bone Metastases Pain

目的分析羟考酮剂量优化对乳腺癌骨转移癌痛患者镇痛效果及安全性的影响。方法前瞻选择2020年1月-2022年1月医院88例乳腺癌骨转移癌痛患者作为研究对象,随机数字表法分为两组各44例,在排除药物禁忌和明确疼痛严重程度后,给予所有患者乙酰氨基酚片口服治疗14d,治疗期间观察组加用低剂量的羟考酮缓释片;对照组治疗前7d加用常规剂量羟考酮缓释片,7d后改服低剂量羟考酮缓释片。治疗14d,比较两组镇痛效果;治疗前、治疗14d,比较两组生命质量[使用乳腺癌患者生命质量测定量表(FACT-B)评估],治疗期间统计不良反应发生情况并比较。结果治疗14d,两组镇痛效果比较,差异无统计学意义(P>0.05);治疗前,两组一般模块(FACT-G)、乳腺癌特异模块评分比较,差异无统计学意义(P>0.05);治疗14d,两组FACT-G、乳腺癌特异模块评分均升高,且观察组FACT-G、乳腺癌特异模块评分均高于对照组,差异有统计学意义(P<0.05);观察组嗜睡、便秘、恶心呕吐、头晕等不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论长期应用低剂量羟考酮缓释片治疗乳腺癌骨转移癌痛,不影响整体镇痛效果,在一定程度上还可减少不良反应发生,患者生命质量提高,有较高的临床应用价值。

Objective To analyze the effect of oxycodone dose optimization on analgesic effect and safety of breast cancer patients with bone metastases pain.Methods 88 patients with cancer pain of bone metastasis of breast cancer in the hospital from January 2020 to January 2022 were selected as the research subjects,a random number table method was used to divide them into 2 groups,with 44 cases in each group.A random number table method was used to divide them into two groups,each with 44 cases.After excluding drug contraindications and clarifying the severity of pain,all patients were given oral acetaminophen tablets for 14 days.During the treatment,the observation group was treated with low-dose Oxycodone Hydrochloride Prolonged-release Tablets.The control group was treated with conventional dose of Oxycodone Hydrochloride Prolonged-release Tablets 7 days before treatment,and then changed to low-dose Oxycodone Hydrochloride Prolonged-release Tablets 7 days later.After 14 days of treatment,the analgesic effects of the two groups were compared;before treatment and 14 days after treatment,the quality of life of the two groups was compared[evaluated by The Functional Assessment of Cancer Therapy-Breast Cancer(FACT-B)],the occurrence of adverse reactions was analyzed and compared during the treatment.Results After 14 days of treatment,there was no statistical significant difference in analgesic effect between the two groups(P>0.05);before treatment,there was no statistical significant difference in the scores of Functional Cancer Therapy-General(FACT-G)and specific modules of breast cancer between the two groups(P>0.05);after 14 days of treatment,the scores of FACT-G and specific modules of breast cancer in both groups were increased,and the scores of FACT-G and specific modules of breast cancer in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05);the total incidence of sleepiness,constipation,nausea and vomiting,dizziness and other adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The long-term application of low-dose Oxycodone Hydrochloride Prolongedrelease Tablets in the treatment of cancer pain of bone metastasis of breast cancer will not affect the overall analgesic effect,and can reduce the occurrence of adverse reactions to a certain extent,the quality of life of patients is improved,with high clinical application value.