探讨CTP联合dCTA评估AIS患者侧支循环状态与梗死核心增长率的相关性

To Investigate the Correlation between Collateral Circulation and Infarct Core Growth Rate in Patients with AIS Evaluated by CTP Combined with dCTA

目的利用CTP联合dCTA探讨AIS患者侧支循环状态与梗死核心增长率的相关性。方法本研究纳入2022年8月-2023年5月经我院收治的AIS患者62例。所有患者均在发病24小时内行头颅CTP检查。记录所有患者发病至其做CTP的总时长。将ASITN/SIR侧支评分0~2分定为侧支循环不良组,3~4分定为侧支循环良好组。根据CTP原始数据可得出梗死核心体积,梗死核心增长率=梗死核心体积/发病至其做CTP的总时长。比较不同侧支循环状态下梗死核心增长率的变化。结果侧支循环不良组患者的梗死核心体积、梗死核心增长率、rTmax大于良好组,rCBF、rCBV及不匹配率小于侧支循环良好组,差异均有统计学意义(P<0.05);rCBF、rCBV及不匹配率与侧支循环评分呈正相关,梗死核心体积、梗死核心体积增长率及rTmax与侧支循环评分呈负相关,差异均有统计学意义(P<0.05)。结论侧支循环差的患者可能有着更快的梗死核心增长率,可以帮助临床医生对患者的进一步处理提供指导意见。

Objective To investigate the correlation between the status of collateral circulation and the growth rate of infarct core in patients with AIS using CTP combined with dCTA.Methods A total of 62 AIS patients admitted to our hospital from August 2022 to May 2023 were included in this study.All patients underwent cranial CTP within 24 hours of onset.The total time from onset to CTP was recorded.According to the ASITN/SIR Collateral score,0-2 was defined as the poor collateral circulation group,and 3-4 was defined as the good collateral circulation group.Infarct core volume can be obtained from the original CTP data,infarct core growth rate=infarct core volume/total time from onset to CTP.The changes of infarct core growth rate under different collateral circulation status were compared.Results The infarct core volume,infarct core growth rate and rTmax in the poor collateral circulation group were higher than those in the good collateral circulation group,and the rCBF,rCBV and mismatch rate were lower than those in the good collateral circulation group,and the differences were statistically significant(P<0.05).rCBF,rCBV and mismatch rate were positively correlated with collateral circulation score,and infarct core volume,infarct core volume growth rate and rTmax were negatively correlated with collateral circulation score,and the differences were statistically significant(P<0.05).Conclusion Patients with poor collateral circulation may have a faster growth rate of infarct core,which can help clinicians to provide guidance for the further management of patients.